Bromelain's activity and potential as an anti-cancer agent: current evidence and perspectives
K Chobotova, AB Vernallis, FAA Majid - Cancer letters, 2010 - Elsevier
The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21)
A Amini, A Ehteda, S Masoumi Moghaddam… - OncoTargets and …, 2013 - Taylor & Francis
Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …
arising from interaction with a number of different biological processes. Several preclinical …
[HTML][HTML] Anticancer properties of bromelain: State-of-the-art and recent trends
Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic
substance with multiple beneficial effects for human health such as anti-inflammatory …
substance with multiple beneficial effects for human health such as anti-inflammatory …
Properties and therapeutic application of bromelain: a review
R Pavan, S Jain, Shraddha… - Biotechnology research …, 2012 - Wiley Online Library
Bromelain belongs to a group of protein digesting enzymes obtained commercially from the
fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and …
fruit or stem of pineapple. Fruit bromelain and stem bromelainare prepared differently and …
Bromelain: biochemistry, pharmacology and medical use
HR Maurer - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Bromelain is a crude extract from the pineapple that contains, among other components,
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …
various closely related proteinases, demonstrating, in vitro and in vivo, antiedematous …
Bromelain-induced apoptosis in GI-101A breast cancer cells
S Dhandayuthapani, HD Perez, A Paroulek… - Journal of medicinal …, 2012 - liebertpub.com
Bromelain is a proteolytic enzyme extracted from the stems and the immature fruits of
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
pineapple that was found to be antitumorigenic in different in vitro models. Bromelain has …
Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis
K Bhui, S Tyagi, AK Srivastava, M Singh… - Molecular …, 2012 - Wiley Online Library
Bromelain, obtained from pineapple, is already in use clinically as adjunct in chemotherapy.
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Our objective was to test its ability to act as a sole anti‐cancer agent. Therefore, we describe …
Regulation of p53, nuclear factor κB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
N Kalra, K Bhui, P Roy, S Srivastava, J George… - Toxicology and applied …, 2008 - Elsevier
Bromelain is a pharmacologically active compound, present in stems and immature fruits of
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
pineapples (Ananas cosmosus), which has been shown to have anti-edematous, anti …
Bromelain reversibly inhibits invasive properties of glioma cells
BB Tysnes, HR Maurert, T Porwol, B Probst, R Bjerkvig… - Neoplasia, 2001 - Elsevier
Bromelain is an aqueous extract from pineapple stem that contains proteinases and exhibits
pleiotropic therapeutic effects, ie, antiedematous, antiinflammatory, antimetastatic …
pleiotropic therapeutic effects, ie, antiedematous, antiinflammatory, antimetastatic …
[HTML][HTML] Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
TC Chang, PL Wei, PT Makondi, WT Chen, CY Huang… - PloS one, 2019 - journals.plos.org
Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …
and targeted therapies. The development of new effective or alternative therapies is …