Patient-derived tumour organoids: a bridge between cancer biology and personalised therapy

W Wu, X Li, S Yu - Acta Biomaterialia, 2022 - Elsevier
Patient-derived tumour organoids (PDOs) have revolutionised our understanding of cancer
biology and the applications of personalised therapies. These advancements are principally …

Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology

L Thorel, M Perréard, R Florent, J Divoux… - … & Molecular Medicine, 2024 - nature.com
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has
broadened the repertoire of preclinical models and progressively revolutionized three …

Patient-derived cancer organoids for precision oncology treatment

MN Pernik, CE Bird, JI Traylor, DD Shi… - Journal of Personalized …, 2021 - mdpi.com
The emergence of three-dimensional human organoids has opened the door for the
development of patient-derived cancer organoid (PDO) models, which closely recapitulate …

Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy

J Mei, X Liu, HX Tian, Y Chen, Y Cao… - Clinical and …, 2024 - Wiley Online Library
Background Organoid technology is an emerging and rapidly growing field that shows
promise in studying organ development and screening therapeutic regimens. Although …

Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine

S Qu, R Xu, G Yi, Z Li, H Zhang, S Qi, G Huang - Molecular Biomedicine, 2024 - Springer
Cancer is associated with a high degree of heterogeneity, encompassing both inter-and
intra-tumor heterogeneity, along with considerable variability in clinical response to common …

The future of cancer therapy: exploring the potential of patient-derived organoids in drug development

CB Avci, BG Bagca, B Shademan… - Frontiers in Cell and …, 2024 - frontiersin.org
Cancer therapy is on the brink of a significant transformation with the inclusion of patient-
derived organoids (PDOs) in drug development. These three-dimensional cell cultures …

The promises and challenges of patient‐derived tumor organoids in drug development and precision oncology

LM Granat, O Kambhampati, S Klosek… - Animal models and …, 2019 - Wiley Online Library
In the era of precision medicine, cancer researchers and oncologists are eagerly searching
for more realistic, cost effective, and timely tumor models to aid drug development and …

Patient-derived tumor organoids for drug repositioning in cancer care: a promising approach in the era of tailored treatment

S Vivarelli, S Candido, G Caruso, L Falzone, M Libra - Cancers, 2020 - mdpi.com
Simple Summary Currently, organoid research is having a growing impact in oncology.
Tumor organoids, directly derived from patients' specimens, can easily be expanded and …

Patient-derived organoids as a model for tumor research

J Wang, X Feng, Z Li, Y Chen, W Huang - Progress in Molecular Biology …, 2022 - Elsevier
Cancer represents a leading cause of death, despite the rapid progress of cancer research,
leading to urgent need for accurate preclinical model to further study of tumor mechanism …

Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank

Z Zhou, L Cong, X Cong - Frontiers in Oncology, 2021 - frontiersin.org
Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …