The tristetraprolin (TTP) family of zinc-finger proteins, TTP, BRF1 and BRF2, regulate the
stability of a subset of mRNAs containing 3′ UTR AU-rich elements (AREs), including …

Tristetraprolin (TTP), the best known member of a class of tandem (R/K) YKTELCX 8 CX 5
CX 3 H zinc finger proteins, can destabilize target mRNAs by first binding to AU-rich …

Tristetraprolin (TTP) is a prototypic family member of CCCH-type tandem zinc-finger domain
proteins that regulate mRNA destabilization in eukaryotic cells. TTP binds to AU-rich …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

AU‐rich elements (AREs) in the 3′ untranslated region (UTR) of numerous mammalian
transcripts function as instability elements that promote rapid mRNA degradation …

Messenger RNA decay is a critical mechanism to control the expression of many
inflammation-and cancer-associated genes. These transcripts are targeted for rapid …

Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability. We
previously showed that TTP acts as a negative regulator of VEGF gene expression in colon …

Abstract AU-rich elements (AREs), residing in the 3′ untranslated region (UTR) of many
labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs …

Adenylate‐and uridylate‐rich element (ARE) motifs are cis‐acting elements present in the
3′ untranslated region of mRNA transcripts that encode many inflammation‐and cancer …

Regulated changes in mRNA stability are critical drivers of gene expression adaptations to
immunological cues. mRNA stability is controlled mainly by RNA-binding proteins (RBPs) …