Multiple sclerosis: an immune or neurodegenerative disorder?

BD Trapp, KA Nave - Annu. Rev. Neurosci., 2008 - annualreviews.org
Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …

Pathology of multiple sclerosis and related inflammatory demyelinating diseases

A Kutzelnigg, H Lassmann - Handbook of clinical neurology, 2014 - Elsevier
This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Multiple sclerosis: lessons from neuropathology

CF Lucchinetti, W Brueck, M Rodriguez… - Seminars in …, 1998 - thieme-connect.com
The focus of multiple sclerosis (MS) research has been on attempts to identify the specific
pathogenic mechanism responsible for producing the multifocal central nervous system …

The spectrum of multiple sclerosis: new lessons from pathology

W Brück, C Stadelmann - Current opinion in neurology, 2005 - journals.lww.com
The spectrum of multiple sclerosis: new lessons from patholo... : Current Opinion in
Neurology The spectrum of multiple sclerosis: new lessons from pathology : Current …

[PDF][PDF] Multiple sclerosis update

CE Markowitz - Am J Manag Care, 2013 - ajmc.s3.amazonaws.com
Multiple sclerosis (MS) is a chronic but incurable disease of the central nervous system
(CNS) that is often diagnosed in the second or third decade of life. It is more common among …

Progressive multiple sclerosis: pathology and pathogenesis

H Lassmann, J Van Horssen, D Mahad - Nature Reviews Neurology, 2012 - nature.com
Major progress has been made during the past three decades in understanding the
inflammatory process and pathogenetic mechanisms in multiple sclerosis (MS) …

A basic overview of multiple sclerosis immunopathology

N Grigoriadis, V Van Pesch - European journal of neurology, 2015 - Wiley Online Library
Multiple sclerosis (MS) is a multi‐component disease characterized by inflammation,
neurodegeneration and failure of central nervous system (CNS) repair mechanisms …

Neurodegeneration in multiple sclerosis: relationship to neurological disability

BD Trapp, RM Ransohoff, E Fisher… - The …, 1999 - journals.sagepub.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Most MS
patients follow a relapsing-remitting course (RR-MS) for 8 to 15 years that transforms into a …

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis

SS Zamvil, L Steinman - Neuron, 2003 - cell.com
Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating
disease that causes relapsing and chronic neurologic impairment. Recent observations …

Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …