Isolation and characterization of a Clostridium botulinum C2 toxin-resistant cell line: evidence for possible involvement of the cellular C2II receptor in growth regulation

G Fritz, P Schroeder, K Aktories - Infection and immunity, 1995 - Am Soc Microbiol
Clostridium botulinum C2 toxin, which consists of the binding component C2II and the
enzyme component C2I, acts on eukaryotic cells by selective ADP-ribosylation of G-actin. To …

Formation of a Biologically Active Toxin Complex of the Binary Clostridium botulinum C2 Toxin without Cell Membrane Interaction

E Kaiser, G Haug, M Hliscs, K Aktories, H Barth - Biochemistry, 2006 - ACS Publications
Clostridium botulinum produces a binary toxin, which is composed of two separate proteins.
The enzyme component, C2I, is an ADP-ribosyltransferase which modifies G-actin of …

The C Terminus of Component C2II ofClostridium botulinum C2 Toxin Is Essential for Receptor Binding

D Blöcker, H Barth, E Maier, R Benz… - Infection and …, 2000 - Am Soc Microbiol
The binary Clostridium botulinum C2 toxin consists of two separate proteins, the binding
component C2II (80.5 kDa) and the actin-ADP-ribosylating enzyme component C2I (49.4 …

[HTML][HTML] The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin …

H Barth, R Roebling, M Fritz, K Aktories - Journal of Biological Chemistry, 2002 - ASBMB
The binary Clostridium botulinum C2 toxin is composed of the enzyme component C2I and
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …

[HTML][HTML] Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

M Eckhardt, H Barth, D Blöcker, K Aktories - Journal of Biological …, 2000 - ASBMB
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic subunit (C2I)
capable of ADP-ribosylating actin and a binding subunit (C2II) that is responsible for …

Response of tissue-cultured cynomolgus monkey kidney cells to botulinum C2 toxin

M Miyake, I Ohishi - Microbial pathogenesis, 1987 - Elsevier
Abstract C 2 toxin (C2T) elaborated by Clostridium botulinum types C and D is composed of
two nonlinked protein components, designated components I and II. The toxin, a mixture of …

Binding of Clostridium botulinum type C neurotoxin to different neuroblastoma cell lines

N Yokosawa, Y Kurokawa, K Tsuzuki… - Infection and …, 1989 - Am Soc Microbiol
Binding of type C neurotoxin (C1 toxin) from Clostridium botulinum (strain Stockholm) to
neuroblastoma cell lines was studied by using biotinylated anti-toxin antibody and avidin …

Purification and characterization of two components of botulinum C2 toxin

I Ohishi, M Iwasaki, G Sakaguchi - Infection and immunity, 1980 - Am Soc Microbiol
Two dissimilar proteins, designated as components I and II, of botulinum C2 toxin elaborated
by strain 92-13 were purified to a homogeneous state. The molecular weights determined by …

Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300

C Sterthoff, AE Lang, C Schwan, A Tauch… - Infection and …, 2010 - Am Soc Microbiol
Clostridium botulinum C2 toxin consists of the binding component C2II and the enzyme
component C2I, which ADP-ribosylates G-actin of eukaryotic cells. Trypsin-activated C2II …

Evidence that botulinum C2 toxin has two dissimilar components

M Iwasaki, I Ohishi, G Sakaguchi - Infection and immunity, 1980 - Am Soc Microbiol
Botulinum C2 toxin produced by most toxigenic and nontoxigenic strains of Clostridium
botulinum types C and D contains two distinct protein components, and these were …