Combination of ALA-induced fluorescence-guided resection and intraoperative open photodynamic therapy for recurrent glioblastoma: case series on a promising …

S Schipmann, M Müther, L Stögbauer, S Zimmer… - Journal of …, 2020 - thejns.org
OBJECTIVE High-grade glioma (HGG) prognosis remains dismal, with inevitable, mostly
local recurrence. Regimens for improving local tumor control are therefore needed …

Instrumentation and light dosimetry for intra-operative photodynamic therapy (PDT) of malignant brain tumours

BC Wilson, PJ Muller, JC Yanch - Physics in Medicine & Biology, 1986 - iopscience.iop.org
A technique is described for uniform light irradiation of the tumour cavity after radical subtotal
malignant brain tumour resection in patients whose tumours have been photosensitised by …

Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid

MC Tetard, M Vermandel, S Mordon, JP Lejeune… - Photodiagnosis and …, 2014 - Elsevier
Photodynamic therapy (PDT) consists of a laser light exposure of tumor cells
photosensitized by general or local administration of a pharmacological agent. Nowadays …

Photodynamic Therapy with a Diode Laser for Implanted Fibrosarcoma in Mice Employing Mono‐L‐Aspartyl Chlorin E6

TA Katsumi, K Aizawa, Y Kuroiwa… - Photochemistry and …, 1996 - Wiley Online Library
The authors performed photodynamic therapy (PDT), avoiding any hyperthermic effects,
using a newly developed diode laser and photosensitizer, mono‐L‐aspar‐tyl chlorin e6 …

[HTML][HTML] Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review

D Bartusik-Aebisher, P Woźnicki, K Dynarowicz… - Brain Sciences, 2023 - mdpi.com
On average, there are about 300,000 new cases of brain cancer each year. Studies have
shown that brain and central nervous system tumors are among the top ten causes of death …

Effect of drug–light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model

LB Li, RC Luo - Lasers in medical science, 2009 - Springer
Our objective was to examine the effect of time intervals between Photofrin injection and
laser irradiation [ie, drug–light interval (DLI)] on the mode of action of Photofrin …

Acridine orange as a novel photosensitizer for photodynamic therapy in glioblastoma

H Osman, D Elsahy, MR Saadatzadeh, KE Pollok… - World neurosurgery, 2018 - Elsevier
Background Photodynamic therapy combines the effects of a chemical agent with the
physical energy from light or radiation to result in lysis of cells. Acridine orange (AO) is a …

[HTML][HTML] Intraoperative photodiagnosis for malignant glioma using photosensitizer talaporfin sodium

J Akimoto, S Fukami, M Ichikawa, A Mohamed… - Frontiers in …, 2019 - frontiersin.org
Objective: The aim of this study was to demonstrate the clinical feasibility of intraoperative
photodiagnosis (PD) of malignant brain tumor using talaporfin sodium (TPS), which is an …

Photodynamic diagnosis and therapy and the brain

H Kostron - Photodynamic Therapy: Methods and Protocols, 2010 - Springer
Photodynamic techniques such as photodynamic diagnosis (PDD), fluorescence-guided
tumour resection (FGR) and photodynamic therapy (PDT) are currently undergoing intensive …

Comparing and combining light dose fractionation and iron chelation to enhance experimental photodynamic therapy with aminolevulinic acid

A Curnow, AJ MacRobert… - Lasers in Surgery and …, 2006 - Wiley Online Library
Abstract Background and Objectives Enhancement of photodynamic therapy (PDT) with 5‐
aminolevulinic acid (ALA) has been demonstrated experimentally using light dose …