Chemotherapy is a leading intervention against cancer. Albeit highly effective,
chemotherapy has a multitude of deleterious side-effects including skeletal muscle wasting …

Abstract Doxorubicin (DOX), a broad-spectrum chemotherapeutic agent for various cancers,
has limited clinical application because of its serious cardiotoxicity, which is due to different …

Cisplatin, a first-line chemotherapeutic agent commonly used to treat various solid tumors,
induce severe adverse effects, especially nephrotoxicity, which largely limits its clinical …

Our current understanding on the molecular mechanisms by which sustained compression
induces skeletal muscle injury is very limited. This study aimed to test the hypothesis that …

Our previous research demonstrated that hepatic-protectant silibinin induced autophagy in
human fibrosarcoma HT1080 cells through reactive oxygen species (ROS) pathway. Pifithrin …

Cisplatin-based therapy is one of the most important chemotherapy treatments for cancers.
However, its efficacy is greatly limited by drug resistance and undesirable side effects …

Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine formula, is used as a remedy for
conditions, and physical weakness. Cancer cachexia is seen in advanced cancer patients …

Cisplatin is widely known as an anti-cancer drug. However, the effects of cisplatin on
mitochondrial function and autophagy-related proteins levels in the skeletal muscle are …

Skeletal muscle atrophy, the most prominent phenotypic feature of cancer cachexia, is often
observed in cancer patients undergoing chemotherapy. Magnolol (M) extracted from …

Statins are the most widely prescribed cholesterol-lowering drugs to reduce the risk of
cardiovascular diseases. Statin-induced myopathy is the major side effect of this class of …