The aim of the present study was to investigate the inhibitory effect of silibinin on SW1990
pancreatic cancer cells. An MTT assay following silibinin treatment demonstrated an …

Muscle atrophy is the loss of skeletal muscle mass during several pathological conditions
such as long-term fasting, aging, cancer, diabetes, sepsis and immune disorders …

The protective effects and mechanisms of DADS on IL‐1β‐mediated oxidative stress and
mitochondrial apoptosis were investigated in C28I2 human chondrocytes. The effect of …

Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and
muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle …

Background Chemotherapy is the first line of treatment for cancer patients. However, the
side effects cause severe muscle atrophy or chemotherapy‐induced cachexia. Previously …

Accumulated evidence suggested the importance of the Rho/Rho‐kinase (ROCK) signaling
pathway in cancer proliferation and invasion. However, its role in colorectal carcinoma …

One of the causes of sarcopenia is that homeostasis between anabolism and catabolism
breaks down due to muscle metabolism changes. Rutin has shown antioxidant and anti …

The pharmacological activity of polyphenolic silibinin from milk thistle (Silybum marianum) is
primarily due to its antioxidant property. However, this study found that silibinin promoted …

Abstract Reactive Oxygen Species (ROS) play an essential role in the pathogenesis of
osteoporosis mainly characterized by excessive osteoclasts (OCs) activity. OCs are rich in …

Background Despite the recent progress in screening and therapy, a majority of prostate
cancer cases eventually attain hormone refractory and chemo-resistant attributes …