Drug resistance is of great concern in cancer treatment because most effective drugs are
limited by the development of resistance following some periods of therapeutic …

Drug resistance remains a major obstacle to the successful use of chemotherapeutic drugs
for cancer therapy. It is well documented that cancer cells can adapt to the presence of …

Environment-mediated drug resistance is a form of de novo drug resistance that protects
tumour cells from the initial effects of diverse therapies. Surviving foci of residual disease …

Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …

The success of current treatment strategies is limited by the development of therapy
resistance as evidenced by recurrence of the primary tumor or distant metastasis …

Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years,
however, acquired resistance has emerged as a daunting challenge to anticancer …

The emergence of clinical drug resistance is still one of the most challenging factors in
cancer treatment effectiveness. Until more recently, the assumption has been that random …

Drug resistance can occur at the individual cellular level or as a result of properties of the
tumor microenvironment. The convoluted vasculature within tumors results in robustly …

Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Tumor drug resistance (TDR) remains a major obstacle for successful treatment of cancer.
Till ninetieth years of past century, resistance of tumors to anticancer drugs was most often …