Background: Effects of blood pressure reduction in persons with grade 1 hypertension are
unclear. Purpose: To investigate whether pharmacologic blood pressure reduction prevents …

Background The benefits of reducing blood pressure are well established, but there remains
uncertainty about whether the magnitude of the effect varies with the initial blood pressure …

Background: Relevant clinical questions not approached by randomized controlled trials
(RCTs) of blood pressure (BP)-lowering treatment can be explored by meta-analyses …

Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

Sixty-eight blood pressure (BP)–lowering randomized controlled trials (defined as
randomized controlled trials comparing active treatment with placebo, or less active …

Background: Type 2 diabetes mellitus is associated with an increased risk of hypertension,
and cardiovascular and renal disease, and it has been recommended that management of …

Background: Antihypertensive treatment is based on randomized controlled trials (RCTs)
started since 1966. Meta-analyses comprehensive of all RCTs but limited to RCTs …

Background: Previous meta-analyses of randomized controlled trials (RCTs) of blood
pressure (BP)-lowering treatment provided overwhelming evidence that treatment markedly …

Background: Randomized controlled trials (RCTs) of blood pressure (BP) lowering lend
themselves to be meta-analyzed to help providing evidence-based recommendations for …

Methods: A database search between 1966 and August 2014 ide ntified 50 eligible
randomized controlled trials for 58 two-drug comparisons (247 006 patients for 1 029 768 …