In this report, we examined the effect of suramin on the cell death induced by glutamate in
cerebellar granule neurons or by staurosporine in NB-2a neuroblastoma cells. Excitotoxicity …

Background. The results of conventional chemotherapy in metastatic colorectal cancer are
discouraging, making it a logical target for new treatment approaches a necessary …

We administered suramin, an anti-parasitic drug and reverse transcriptase inhibitor, to 15
patients with metastatic cancer. This compound is known to inhibit the binding of growth …

The effect of suramin on B16F10 melanoma lung colonies and M5076 reticulosarcoma liver
metastasis formation was evaluated in C57B1/6 female mice. Single iv doses of 200 mg/kg …

Purpose: Suramin has been shown to have efficacy in treatment of prostate cancer. In the
present study we evaluated distribution of [14C] suramin in tissues over time following a …

The polyanionic compound suramin can inhibit the proliferation of cells of various origin,
including from breast cancer. We have studied the effects of suramin on cell cycle kinetics …

Although suramin has shown promise in preliminary clinical trials as an antineoplastic
agent, it is unclear if its mode of action is predominately extracellular or intracellular. We …

PURPOSE: To determine the toxicity, efficacy, and pharmacology of suramin in patients with
recurrent or progressive recurrent high-grade gliomas. PATIENTS AND METHODS: Fifty …

Purpose: Suramin, a polysulfonated naphthylurea, has been shown to be effective in the
treatment of several cancers. We have reported that suramin, at dose concentrations higher …

Background: Suramin is a polysulfonated urea recently tested in clinical trials as an
anticancer agent. Purpose: To define tumor types for further clinical testing of suramin, we …