Suramin analogs are polyanionic naphthylureas structurally related to suramin, an antitumor
agent with a narrow therapeutic window. The angiostatic activities of suramin and 16 …

Suramin, an antitrypanosomal agent used since the early 1920s for the treatment of
onchocerciasis and African sleeping sickness is now under active investigation as an …

Suramin was administered to 49 patients in a Phase I cancer trial with real-time
pharmacokinetic monitoring and dose individualization to achieve targeted mean plasma …

The present experiment was undertaken to study what types of human cancers are
responsive to the antiproliferative effects of suramin. The human malignant cells used were …

Suramin, a highly sulfonated drug, has been reported to be effective against several human
malignancies in vitro and in vivo, and currently is undergoing clinical trials against prostate …

He has been intimately associated with the development of the EORTC since its inception in
1963, becoming President from 1974 to 1978. He has also been Chairman of the Advisory …

PURPOSE Suramin is an anticancer agent with a narrow therapeutic window and a terminal
half-life of 45 to 55 days. These characteristics make it necessary to control accurately the …

Abstract SURAMIN INHIBITS THE stimulation of brain tumor deoxyribonucleic acid synthesis
in vitro at concentrations of 200 to 400 mg/ml. This report evaluates suramin in the rodent 9L …

Suramin, a non-specific growth factor antagonist, has been reported to have pleiotrophic
action on the proliferation of some kinds of tumours and has therefore attracted attention as …

The effect of suramin on the in vivo growth of 4 human malignant melanoma
xenotransplantation lines in nude mice was studies. The drug (multiple ip injections of 80 …