Human mitochondrial DNA (mtDNA) is a multi-copy extra-chromosomal genetic element,
which is exposed to a high steady-state level of reactive oxygen species and free radicals …

Accumulation of somatic mutations in the mitochondrial DNA (mtDNA) is a major contributor
to human aging and degenerative diseases. Rapid progress has been made in unraveling …

The small mammalian mitochondrial DNA (mtDNA) is very gene dense and encodes factors
critical for oxidative phosphorylation. Mutations of mtDNA cause a variety of human …

Accumulating evidence has emphasized the role of genetic factors in the development of
aging and degenerative diseases. Mitochondrial DNA (mtDNA), that codes for protein …

This paper reviews the current state of knowledge of the contribution of mitochondrial DNA
(mtDNA) mutations to the phenotype of aging. Its major focus is on the discovery of deletions …

Mitochondrial DNA (mtDNA) that codes protein subunits essential for the maintenace of
mitochondrial ATP synthesis system acquires mutations at a much higher rate than that in …

Mitochondrial DNA (mtDNA) is a naked double-stranded circular extrachromosomal genetic
element continuously exposed to the matrix that contains great amounts of reactive oxygen …

A wide variety of mitochondrial DNA (mtDNA) mutations have recently been identified in
degenerative diseases of the brain, heart, skeletal muscle, kidney and endocrine system …

Advances in understanding of mitochondrial physiology and genetics in relation to
pathology have exploded in the last decade. Paralleling this increase has been an active …

Mitochondrial DNA (mtDNA) mutations appear to be associated with a wide spectrum of
human disorders and proposed to be a potential contributor of aging. However, in an age …