Background—We previously demonstrated that defective interdomain interaction between N-
terminal (0 to 600) and central regions (2000 to 2500) of ryanodine receptor 2 (RyR2) …

Rationale Heart failure is a multimodal disorder, of which disrupted Ca 2+ homeostasis is a
hallmark. Central to Ca 2+ homeostasis is the major cardiac Ca 2+ release channel–the …

Abnormal Ca2+ cycling is important in various cardiac diseases. Evidence has accumulated
that dysregulation of Ca2+ release from the ryanodine receptor (RyR2) plays a significant …

Abstract Ryanodine receptor 2 (RyR2) is an ion channel in the heart responsible for
releasing into the cytosol most of the Ca 2+ required for contraction. Proper regulation of …

Rationale: Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have
been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed …

The NH 2-terminal region (residues 1–543) of the cardiac ryanodine receptor (RyR2)
harbors a large number of mutations associated with cardiac arrhythmias and …

This Controversies in Research article discusses the hypothesis that protein kinase A (PKA)-
mediated phosphorylation of the Ryanodine Receptor (RyR) at a single serine (RyRS2808) …

Cardiac ryanodine receptor gene (RyR2) mutations cause fatal arrhythmogenic diseases
such as catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right …

Cardiac ryanodine receptor (RyR2) is a large Ca2+ release channel in the sarcoplasmic
reticulum and indispensable for excitation-contraction coupling in the heart. RyR2 is …

Cardiac ryanodine receptor type 2 plays a key role in excitation–contraction coupling. The
ryanodine receptor type 2 channel protein is modulated by various post-translational …