In light of the utility and increasing ubiquity of mouse models of genetic and neurological
disease, I describefully automated pipelines for the investigation of structural microscopic …

Brain circuits are highly interconnected three-dimensional structures fabricated from
components ranging vastly in size; from cell bodies to individual synapses. While neuronal …

The ability to image the cortex laminar arrangements in vivo is one of the holy grails of
neuroscience. Recent studies have visualized the cortical layers ex vivo and in vivo (on a …

This chapter discusses structural MRI (sMRI) techniques to image the brain anatomy, with a
focus on diffusion MRI (dMRI). Conventional sMRI, including T1-, T2-, T2*-weighted MRI …

Advances in multimodal MRI have enabled scientists to probe neurological phenomena
across scales. By characterizing the brain at the molecular, cellular, and macroscopic levels …

Magnetic resonance microscopy (MRM), when used in conjunction with active staining, can
produce high-resolution, high-contrast images of the mouse brain. Using MRM, we imaged …

Spatially resolved nuclear magnetic resonance (NMR) techniques provide structural,
metabolic and functional insights into the central nervous system and allow for repetitive in …

In recent years, development of various imaging, recording and stimulation tools are rapidly
advancing our knowledge of the human anatomy and its underlying interconnections. As a …

The MRI signal is dependent upon a number of sub-voxel properties of tissue, which makes
it potentially able to detect changes occurring at a scale much smaller than the image …

The ability to map brain microstructures such as axonal fibers and myelin content is critical in
improving our understanding of brain organization and neurological diseases. Quantitative …