The Effect of Alcohol and Opioid Withdrawal on Single-Cell Glia and Neuronal Gene Expression in the Visceral Emotional Neuraxis
S O'Sullivan - 2021 - search.proquest.com
Alcohol and opioid abuse pose major social, economic, and health-related consequences to
society. These depressants have distinct yet overlapping effects on mammalian systems …
society. These depressants have distinct yet overlapping effects on mammalian systems …
Similarities in alcohol and opioid withdrawal syndromes suggest common negative reinforcement mechanisms involving the interoceptive antireward pathway
SJ O'Sullivan, JS Schwaber - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Alcohol and opioids are two major contributors to so-called deaths of despair. Though the
effects of these substances on mammalian systems are distinct, commonalities in their …
effects of these substances on mammalian systems are distinct, commonalities in their …
Neurocircuitry of alcohol addiction: synthesis from animal models
GF Koob - Handbook of clinical neurology, 2014 - Elsevier
Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …
Single cell scale neuronal and glial gene expression and putative cell phenotypes and networks in the nucleus tractus solitarius in an alcohol withdrawal time series
SJ O'Sullivan, D McIntosh-Clarke, J Park… - Frontiers in Systems …, 2021 - frontiersin.org
Alcohol withdrawal syndrome (AWS) is characterized by neuronal hyperexcitability,
autonomic dysregulation, and severe negative emotion. The nucleus tractus solitarius (NTS) …
autonomic dysregulation, and severe negative emotion. The nucleus tractus solitarius (NTS) …
[PDF][PDF] Single neuronal and glial gene expression in the nucleus tractus solitarius in an alcohol withdrawal time series reveals novel cellular phenotypes and networks
SJ O'Sullivan, D McIntosh-Clarke, J Park, R Vadigepalli… - 2021 - pdfs.semanticscholar.org
Alcohol withdrawal syndrome (AWS) is characterized by neuronal hyperexcitability,
autonomic dysregulation, and severe negative emotion. The nucleus tractus solitarius (NTS) …
autonomic dysregulation, and severe negative emotion. The nucleus tractus solitarius (NTS) …
Single-cell glia and neuron gene expression in the central amygdala in opioid withdrawal suggests inflammation with correlated gut dysbiosis
SJ O'Sullivan, E Malahias, J Park… - Frontiers in …, 2019 - frontiersin.org
Drug-seeking in opioid dependence is due in part to the severe negative emotion
associated with the withdrawal syndrome. It is well-established that negative emotional …
associated with the withdrawal syndrome. It is well-established that negative emotional …
[HTML][HTML] Neurobiology of alcohol dependence: focus on motivational mechanisms
Alcoholism is a debilitating disorder for the individual and very costly for society. A major
goal of alcohol research is to understand the neural underpinnings associated with the …
goal of alcohol research is to understand the neural underpinnings associated with the …
Driving the downward spiral: Alcohol‐induced dysregulation of extended amygdala circuits and negative affect
Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities
globally. Affective disturbances, including stress, depression, and anxiety, are highly …
globally. Affective disturbances, including stress, depression, and anxiety, are highly …
Neurobiologic advances from the brain disease model of addiction
ND Volkow, GF Koob… - Evaluating the Brain …, 2022 - api.taylorfrancis.com
This article reviews scientific advances in the prevention and treatment of substance-use
disorder and related developments in public policy. In the past two decades, research has …
disorder and related developments in public policy. In the past two decades, research has …
Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder
GF Koob - Behavioral neurobiology of alcohol addiction, 2013 - Springer
Alcoholism can be defined by a compulsion to seek and take drug, loss of control in limiting
intake, and the emergence of a negative emotional state when access to the drug is …
intake, and the emergence of a negative emotional state when access to the drug is …