CHA2DS2-VASc and HAS-BLED scores and activated partial thromboplastin time for prediction of high plasma concentration of dabigatran at trough

S Owada, H Tomita, T Kinjo, Y Ishida, T Itoh… - Thrombosis …, 2015 - Elsevier
Introduction Although dabigatran, an oral direct thrombin inhibitor, does not require routine
monitoring, high plasma concentration of dabigatran (PDC) at trough level is shown to be a …

Dabigatran concentration: variability and potential bleeding prediction in “real–life” patients with atrial fibrillation

P Šinigoj, RE Malmström, N Vene… - Basic & clinical …, 2015 - Wiley Online Library
Routine laboratory monitoring is currently not recommended in patients receiving dabigatran
despite its considerable variation in plasma concentration. However, in certain clinical …

Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in …

K Okubo, T Kuwahara, K Takagi, M Takigawa… - The American Journal of …, 2015 - Elsevier
Dabigatran is a direct thrombin inhibitor that has been approved for preventing stroke in
patients with atrial fibrillation. In this study, we aimed to assess the associations between the …

Dabigatran plasma concentration indicated the risk of patients with non-valvular atrial fibrillation

Z Zhu, Z Shen, A Shi, C Su, J Mao, H Tao, F Xu, Z Hu… - Heart and Vessels, 2022 - Springer
This study aimed to evaluate the variability of dabigatran plasma concentration and the
association with clinical events in Chinese patients treated with dabigatran etexilate (DE) for …

Factors influencing trough and 90-minute plasma dabigatran etexilate concentrations among patients with non-valvular atrial fibrillation

H Tomita, T Araki, T Kadokami, S Yamada… - Thrombosis …, 2016 - Elsevier
Introduction Dabigatran etexilate, a direct oral anti-coagulation agent, is used in the
prevention of thromboembolism in patients with non-valvular atrial fibrillation (NVAF) …

Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran etexilate

J Douxfils, JM Dogné, F Mullier… - Thrombosis and …, 2013 - thieme-connect.com
Ways to monitor dabigatran etexilate (DE) therapy would be useful in certain situations.
Functional assays such as aPTT or Hemoclot® Thrombin Inhibitor (HTI) have been …

Coagulation assays and plasma fibrinogen concentrations in real‐world patients with atrial fibrillation treated with dabigatran

PKL Chin, DM Patterson, M Zhang… - British journal of …, 2014 - Wiley Online Library
Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine the
correlation between plasma dabigatran concentrations and the three screening coagulation …

Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross‐sectional pharmacodynamic study based on peak and trough plasma levels

EM Hawes, AM Deal, D Funk‐Adcock… - … of Thrombosis and …, 2013 - Wiley Online Library
Background Knowledge of anticoagulation status during dabigatran therapy may be
desirable in certain clinical situations. Objective To determine the coagulation tests that are …

Real-world variability in dabigatran levels in patients with atrial fibrillation: reply

NC Chan, J Hirsh, JS Ginsberg… - Journal of Thrombosis …, 2015 - jthjournal.org
Douxfils et al. are concerned about the wide range of trough dabigatran levels among
individuals reported in our cohort (< 30 ng mL À1 to 510 ng mL À1)[1], citing their ex vivo …

Real-world variability in dabigatran levels in patients with atrial fibrillation: comment

J Douxfils, B Chatelain, JM Dogné… - Journal of Thrombosis and …, 2015 - jthjournal.org
We read with interest the recent prospective observational study by Chan et al.[1] The
authors aimed to investigate the interpatient and intrapatient variabilities in dabigatran …