CHA2DS2-VASc and HAS-BLED scores and activated partial thromboplastin time for prediction of high plasma concentration of dabigatran at trough
Introduction Although dabigatran, an oral direct thrombin inhibitor, does not require routine
monitoring, high plasma concentration of dabigatran (PDC) at trough level is shown to be a …
monitoring, high plasma concentration of dabigatran (PDC) at trough level is shown to be a …
Dabigatran concentration: variability and potential bleeding prediction in “real–life” patients with atrial fibrillation
P Šinigoj, RE Malmström, N Vene… - Basic & clinical …, 2015 - Wiley Online Library
Routine laboratory monitoring is currently not recommended in patients receiving dabigatran
despite its considerable variation in plasma concentration. However, in certain clinical …
despite its considerable variation in plasma concentration. However, in certain clinical …
Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in …
K Okubo, T Kuwahara, K Takagi, M Takigawa… - The American Journal of …, 2015 - Elsevier
Dabigatran is a direct thrombin inhibitor that has been approved for preventing stroke in
patients with atrial fibrillation. In this study, we aimed to assess the associations between the …
patients with atrial fibrillation. In this study, we aimed to assess the associations between the …
Dabigatran plasma concentration indicated the risk of patients with non-valvular atrial fibrillation
Z Zhu, Z Shen, A Shi, C Su, J Mao, H Tao, F Xu, Z Hu… - Heart and Vessels, 2022 - Springer
This study aimed to evaluate the variability of dabigatran plasma concentration and the
association with clinical events in Chinese patients treated with dabigatran etexilate (DE) for …
association with clinical events in Chinese patients treated with dabigatran etexilate (DE) for …
Factors influencing trough and 90-minute plasma dabigatran etexilate concentrations among patients with non-valvular atrial fibrillation
H Tomita, T Araki, T Kadokami, S Yamada… - Thrombosis …, 2016 - Elsevier
Introduction Dabigatran etexilate, a direct oral anti-coagulation agent, is used in the
prevention of thromboembolism in patients with non-valvular atrial fibrillation (NVAF) …
prevention of thromboembolism in patients with non-valvular atrial fibrillation (NVAF) …
Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran etexilate
Ways to monitor dabigatran etexilate (DE) therapy would be useful in certain situations.
Functional assays such as aPTT or Hemoclot® Thrombin Inhibitor (HTI) have been …
Functional assays such as aPTT or Hemoclot® Thrombin Inhibitor (HTI) have been …
Coagulation assays and plasma fibrinogen concentrations in real‐world patients with atrial fibrillation treated with dabigatran
PKL Chin, DM Patterson, M Zhang… - British journal of …, 2014 - Wiley Online Library
Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine the
correlation between plasma dabigatran concentrations and the three screening coagulation …
correlation between plasma dabigatran concentrations and the three screening coagulation …
Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross‐sectional pharmacodynamic study based on peak and trough plasma levels
EM Hawes, AM Deal, D Funk‐Adcock… - … of Thrombosis and …, 2013 - Wiley Online Library
Background Knowledge of anticoagulation status during dabigatran therapy may be
desirable in certain clinical situations. Objective To determine the coagulation tests that are …
desirable in certain clinical situations. Objective To determine the coagulation tests that are …
Real-world variability in dabigatran levels in patients with atrial fibrillation: reply
Douxfils et al. are concerned about the wide range of trough dabigatran levels among
individuals reported in our cohort (< 30 ng mL À1 to 510 ng mL À1)[1], citing their ex vivo …
individuals reported in our cohort (< 30 ng mL À1 to 510 ng mL À1)[1], citing their ex vivo …
Real-world variability in dabigatran levels in patients with atrial fibrillation: comment
J Douxfils, B Chatelain, JM Dogné… - Journal of Thrombosis and …, 2015 - jthjournal.org
We read with interest the recent prospective observational study by Chan et al.[1] The
authors aimed to investigate the interpatient and intrapatient variabilities in dabigatran …
authors aimed to investigate the interpatient and intrapatient variabilities in dabigatran …
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