Monitoring of dabigatran therapy using Hemoclot® Thrombin Inhibitor assay in patients with atrial fibrillation

M Samoš, L Stančiaková, J Ivanková, J Staško… - Journal of thrombosis …, 2015 - Springer
Dabigatran, a new direct thrombin inhibitor, achieves strong anticoagulation that is more
predictable than warfarin. Nevertheless, a patient on dabigatran therapy (DT) may suffer …

Real‐world variability in dabigatran levels in patients with atrial fibrillation

NC Chan, M Coppens, J Hirsh… - … of Thrombosis and …, 2015 - Wiley Online Library
Background In clinical practice, physicians are given the choice of selecting one of two
dabigatran doses based on patient characteristics, with the lower dose typically used in …

[HTML][HTML] Relationship between plasma dabigatran concentration and activated partial thromboplastin time in Japanese patients with non-valvular atrial fibrillation

D Shimomura, Y Nakagawa, H Kondo, T Tamura… - Journal of …, 2015 - Elsevier
Background Activated partial thromboplastin time (aPTT) is recommended for monitoring
anticoagulant activity in dabigatran-treated patients; however, there are limited data in …

Monitoring of low dabigatran concentrations: diagnostic performance at clinically relevant decision thresholds

F Haertig, S Poli, M Ebner, I Birschmann, J Kuhn… - Journal of Thrombosis …, 2020 - Springer
The direct oral anticoagulant dabigatran does not require therapeutic drug monitoring,
however emergency measurements are gaining importance. Current assays feature good …

A systematic review and meta‐analysis of dabigatran peak and trough concentration in adults

JW Ng, NA Mohd Tahir, PKL Chin… - British Journal of …, 2022 - Wiley Online Library
Dabigatran etexilate is an oral direct thrombin inhibitor used in preventing thromboembolism
in patients with atrial fibrillation and several other conditions. Routine dabigatran …

On the monitoring of dabigatran treatment in “real life” patients with atrial fibrillation

M Skeppholm, P Hjemdahl, JP Antovic, J Muhrbeck… - Thrombosis research, 2014 - Elsevier
Introduction The oral direct thrombin inhibitor dabigatran is increasingly used to prevent
thromboembolic stroke in patients with atrial fibrillation (AF). Routine laboratory monitoring is …

A proposal for dose‐adjustment of dabigatran etexilate in atrial fibrillation guided by thrombin time

PKL Chin, DFB Wright, DM Patterson… - British journal of …, 2014 - Wiley Online Library
Dabigatran is an oral anticoagulant that is increasingly used for atrial fibrillation (AF).
Presently, many authorities state that routine laboratory coagulation monitoring is not …

The assessment of anticoagulant activity to predict bleeding outcome in atrial fibrillation patients receiving dabigatran etexilate

YT Chang, YF Hu, JN Liao, CM Chern… - Blood Coagulation & …, 2016 - journals.lww.com
Special circumstances may require the measurement of the anticoagulant effect of
dabigatran etexilate. No data currently link any given coagulation test to bleeding outcomes …

[HTML][HTML] Frequency and predictors of bleeding complications associated with anti-coagulant therapy using dabigatran in Japanese patients with atrial fibrillation

H Katoh, T Nozue, T Asada, K Nakashima… - American Journal of …, 2014 - ncbi.nlm.nih.gov
Background: Few data exist regarding frequency and predictors of bleeding complications
associated with anticoagulant therapy using dabigatran in Japanese patients with atrial …

[HTML][HTML] Global Thrombosis Test–a possible monitoring system for the effects and safety of dabigatran

K Otsui, DA Gorog, J Yamamoto, T Yoshioka, S Iwata… - Thrombosis …, 2015 - Springer
Background Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of
stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran …