cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

Background: A common phenotype associated with heart failure is the development of
cardiac hypertrophy. Cardiac hypertrophy occurs in response to stress, such as …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Increasing evidence suggests that oxidative and nitrosative stress play an important role in
regulation of cardiac myocyte growth and survival. The cardiovascular system is …

Cardiac hypertrophy (CH) is an adaptive response of the heart to pressure overload. It is a
common pathological feature in the natural course of some major cardiovascular diseases …

Although p38 mitogen-activated protein kinase (MAPK) is known to have a role in ischemic
heart disease and many other diseases, its contribution to the pathobiology of right …

Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative
to antioxidant defense, has been shown to play an important role in the pathophysiology of …

Aims Hypertensive cardiac hypertrophy is associated with reduced coronary flow reserve,
but its impact on coronary flow regulation and vasomotor function remains incompletely …

The mitogen-activated protein kinase (MAPK) signaling pathways serve as pivotal
transducers of diverse biologic functions including cell growth, differentiation, proliferation …

Recent studies suggest that cardiac fibroblast-specific p38α MAPK contributes to the
development of cardiac hypertrophy, but the underlying mechanism is unknown. Our study …