Airway submucosal glands are sites of high expression of the cystic fibrosis transmembrane
conductance regulator (CFTR) Cl− channel and contribute to fluid homeostasis in the lung …

The serous acini of airway submucosal glands are important for fluid secretion in the lung.
Serous cells are also sites of expression of the cystic fibrosis transmembrane conductance …

Airway submucosal glands contribute to airway surface liquid (ASL) composition and
volume, both important for lung mucociliary clearance. Serous acini generate most of the …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Cystic fibrosis (CF) airway disease arises from defective innate defenses, especially
defective mucus clearance of microorganisms. Airway submucosal glands secrete most …

Fluid secretion by epithelial cells can be modulated by agents that activate Cl-channels in
the apical membrane. To sustain secretion, Cl-influx across the basolateral membrane must …

Cytoplasmic Ca 2+ is a master regulator of airway physiology; it controls fluid, mucus, and
antimicrobial peptide secretion, ciliary beating, and smooth muscle contraction. The focus of …

Cystic fibrosis (CF), which is caused by mutations in CFTR, affects many tissues, including
the lung. Submucosal gland serous acinar cells are primary sites of fluid secretion and …

The human airway is protected by an efficient innate defense mechanism that requires
healthy secretion of airway surface liquid (ASL) to clear pathogens from the lungs. Most of …

Key points• The mechanisms of anion and fluid transport by airway submucosal glands are
not well understood and may differ from those in surface epithelium.• The Calu‐3 cell line is …