A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D

R Leth-Larsen, P Garred, H Jensenius… - The Journal of …, 2005 - journals.aai.org
Abstract Surfactant protein D (SP-D) plays important roles in the host defense against
infectious microorganisms and in regulating the innate immune response to a variety of …

[HTML][HTML] Polymorphisms in the human surfactant protein-D (SFTPD) gene: strong evidence that serum levels of surfactant protein-D (SP-D) are genetically influenced

K Heidinger, IR König, A Bohnert, A Kleinsteiber… - Immunogenetics, 2005 - Springer
The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity.
Epidemiological studies described associations between single nucleotide polymorphisms …

[HTML][HTML] Surfactant protein A and surfactant protein D variation in pulmonary disease

GL Sorensen, S Husby, U Holmskov - Immunobiology, 2007 - Elsevier
Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate
immunity. The proteins are host defense lectins, belonging to the collectin family which also …

[HTML][HTML] Surfactant protein D in respiratory and non-respiratory diseases

GL Sorensen - Frontiers in medicine, 2018 - frontiersin.org
Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune
defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts …

Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster

K Kölble, J Lu, SE Mole, S Kaluz, KBM Reid - Genomics, 1993 - Elsevier
Pulmonary surfactant consists of a complex mixture of phospholipids and several proteins
essential to normal respiratory function. Two of the surfactant proteins, SP-A and SP-D …

The roles of surfactant proteins A and D in innate immunity

PR Lawson, KBM Reid - Immunological reviews, 2000 - Wiley Online Library
Research over the last decade on the surfactant proteins SP‐A and SP‐D suggests roles
beyond surfactant lipid homeostasis, involving their participation in innate immune defence …

Immunomodulatory roles of surfactant proteins A and D: implications in lung disease

AM Pastva, JR Wright, KL Williams - Proceedings of the American …, 2007 - atsjournals.org
Surfactant, a lipoprotein complex, was originally described for its essential role in reducing
surface tension at the air–liquid interface of the lung; however, it is now recognized as being …

[PDF][PDF] Surfactant proteins SP-A and SP-D in human health and disease

U Kishore, AL Bernal, MF Kamran… - ARCHIVUM …, 2005 - researchgate.net
Summary Surfactant proteins A (SP-A) and D (SP-D) are lung surfactant-associated
hydrophilic proteins that have been implicated in surfactant homeostasis and pulmonary …

[HTML][HTML] Surfactant protein-D and pulmonary host defense

EC Crouch - Respiratory research, 2000 - Springer
Abstract Surfactant protein-D (SP-D) participates in the innate response to inhaled
microorganisms and organic antigens, and contributes to immune and inflammatory …

Surfactant protein D alters allergic lung responses in mice and human subjects

EB Brandt, MK Mingler, MD Stevenson, N Wang… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Surfactant protein (SP) D has been proposed to be protective in allergic
airway responses. OBJECTIVE: We aimed to determine the effect of SP-D deficiency on …