IL-22 is a Th17/Th22 cytokine that is increased in asthma. However, recent animal studies
showed controversial findings in the effects of IL-22 in allergic asthma. To determine the role …

Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells
and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease …

Background Increased IL-17A production has been associated with more severe asthma;
however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in …

BACKGROUND: The IL-1 family cytokine IL-33 is involved in the induction of airway
inflammation in allergic patients and after viral infection. Several cell types, including CD4+ …

Aim of this study: Airway remodeling, which encompasses structural changes in airway is a
main feature of asthma. Interleukin-33 (IL-33) has been reported to be a vital cytokine in …

Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic
inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction …

Background Influenza virus triggers severe asthma exacerbations for which no adequate
treatment is available. It is known that IL-33 levels correlate with exacerbation severity, but …

Abstract IL-33 is an IL-1-related cytokine which has been implicated in Th2-associated
biology and allergic diseases in humans and mice. IL-33 stimulates Th2 cells, mast cells …

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell …

ABSTRACT Objective: Interleukin (IL)-33 is involved in the development of lung
inflammation by inducing or amplifying Th2 type-mediated responses in various animal …