Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

M Diepenbruck, G Christofori - Current opinion in cell biology, 2016 - Elsevier
An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during
embryonic development and organogenesis. During an EMT, epithelial cells lose their …

Epithelial–mesenchymal plasticity: a central regulator of cancer progression

X Ye, RA Weinberg - Trends in cell biology, 2015 - cell.com
The epithelial–mesenchymal transition (EMT) program has emerged as a central driver of
tumor malignancy. Moreover, the recently uncovered link between passage through an EMT …

Revisiting epithelial‐mesenchymal transition in cancer metastasis: the connection between epithelial plasticity and stemness

TT Liao, MH Yang - Molecular oncology, 2017 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is an important process in embryonic
development, fibrosis, and cancer metastasis. During cancer progression, the activation of …

[HTML][HTML] Epithelial-to-mesenchymal plasticity harnesses endocytic circuitries

S Corallino, MG Malabarba, M Zobel… - Frontiers in …, 2015 - frontiersin.org
The ability of cells to alter their phenotypic and morphological characteristics, known as
cellular plasticity, is critical in normal embryonic development and adult tissue repair and …

Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells

G Ouyang, Z Wang, X Fang, J Liu, CJ Yang - Cellular and Molecular Life …, 2010 - Springer
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that
allows polarized, well-differentiated epithelial cells to convert to unpolarized, motile …

[HTML][HTML] Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

SJ Serrano-Gomez, M Maziveyi, SK Alahari - Molecular cancer, 2016 - Springer
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …

[HTML][HTML] Epigenetic control of epithelial-mesenchymal-transition in human cancer

T Kiesslich, M Pichler… - … and clinical oncology, 2013 - spandidos-publications.com
Abstract Development and tissue homeostasis as well as carcinogenesis share the
evolutionary conserved process of epithelial-mesenchymal transition (EMT). EMT enables …

[HTML][HTML] Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis

K Campbell - Current opinion in cell biology, 2018 - Elsevier
The epithelial-to-mesenchymal transition (EMT) plays crucial roles during development, and
inappropriate activation of EMTs are associated with tumor progression and promoting …

[PDF][PDF] Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

[HTML][HTML] EMT: when epithelial cells decide to become mesenchymal-like cells

R Kalluri - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development,
and this process is re-engaged in adults during wound healing, tissue regeneration, organ …