Contribution of epithelial plasticity to therapy resistance
PG Santamaría, G Moreno-Bueno, A Cano - Journal of clinical medicine, 2019 - mdpi.com
Therapy resistance is responsible for tumour recurrence and represents one of the major
challenges in present oncology. Significant advances have been made in the understanding …
challenges in present oncology. Significant advances have been made in the understanding …
[HTML][HTML] the role of the EMT program in regulating the immune response in carcinoma
The Epithelial-to-Mesenchymal Transition (EMT) is a cell-biological process that operates
during embryonic development, wound-healing, and carcinoma progression. During this …
during embryonic development, wound-healing, and carcinoma progression. During this …
Survival outcomes in cancer patients predicted by a partial EMT gene expression scoring metric
Metastasis is a significant contributor to morbidity and mortality for many cancer patients and
remains a major obstacle for effective treatment. In many tissue types, metastasis is fueled …
remains a major obstacle for effective treatment. In many tissue types, metastasis is fueled …
The mesenchymal-to-epithelial transition in somatic cell reprogramming
The epithelial-to-mesenchymal transition (EMT) is a process that confers migratory
characteristics to epithelial cells. It is a major force driving embryonic development, tissue …
characteristics to epithelial cells. It is a major force driving embryonic development, tissue …
Dynamism, sensitivity, and consequences of mesenchymal and Stem‐Like phenotype of cancer cells
P Gener, J Seras-Franzoso, PG Callejo… - Stem Cells …, 2018 - Wiley Online Library
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer
cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against …
cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against …
[HTML][HTML] Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth
Simple Summary In this manuscript, we used a non-genetically manipulated EMT/MET cell
line model to demonstrate that epithelial mesenchymal plasticity occurring in normal cells …
line model to demonstrate that epithelial mesenchymal plasticity occurring in normal cells …
Phenotypic plasticity and epithelial‐mesenchymal transitions in cancer and normal stem cells?
C Scheel, RA Weinberg - International journal of cancer, 2011 - Wiley Online Library
Cancer stem cells (CSCs) are similar to normal stem cells in their ability to self‐renew and to
generate large populations of more differentiated descendants. In contrast to the hierarchical …
generate large populations of more differentiated descendants. In contrast to the hierarchical …
[HTML][HTML] OVOL guides the epithelial-hybrid-mesenchymal transition
Metastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its
reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial …
reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial …
PyMT-1099, a versatile murine cell model for EMT in breast cancer
M Saxena, RKR Kalathur, M Neutzner, G Christofori - Scientific reports, 2018 - nature.com
An epithelial-mesenchymal transition (EMT) has been implicated in cancer metastasis, drug
resistance, and in conferring stem cell-like traits to cancer cells. Most studies investigating …
resistance, and in conferring stem cell-like traits to cancer cells. Most studies investigating …
Calcium signaling induces a partial EMT
RJ Norgard, JR Pitarresi, R Maddipati… - EMBO …, 2021 - embopress.org
Epithelial plasticity, or epithelial‐to‐mesenchymal transition (EMT), is a well‐recognized
form of cellular plasticity, which endows tumor cells with invasive properties and alters their …
form of cellular plasticity, which endows tumor cells with invasive properties and alters their …