Shaping of hepatic ischemia/reperfusion events: the crucial role of mitochondria

JS Teodoro, RT Da Silva, IF Machado… - Cells, 2022 - mdpi.com
Hepatic ischemia reperfusion injury (HIRI) is a major hurdle in many clinical scenarios,
including liver resection and transplantation. Various studies and countless surgical events …

[HTML][HTML] Recent insights into mitochondrial targeting strategies in liver transplantation

RM Martins, JS Teodoro, E Furtado… - … journal of medical …, 2018 - ncbi.nlm.nih.gov
Abstract Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal
activity of mitochondria in the hepatic parenchyma. This potential dysfunction of …

Preservation of mitochondrial health in liver ischemia/reperfusion injury

IF Machado, CM Palmeira, AP Rolo - Biomedicines, 2023 - mdpi.com
Liver ischemia-reperfusion injury (LIRI) is a major cause of the development of
complications in different clinical settings such as liver resection and liver transplantation …

Mitochondrial quality control in hepatic ischemia-reperfusion injury

LS Wang, ZJ Feng, X Ma, K Li, XY Li, Y Tang, C Peng - Heliyon, 2023 - cell.com
Hepatic ischemia-reperfusion injury is a phenomenon in which exacerbating damage of liver
cells due to restoration of blood flow following ischemia during liver surgery, especially …

Pre‐conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

C Hu, L Li - Journal of cellular and molecular medicine, 2017 - Wiley Online Library
The liver, the largest organ with multiple synthesis and secretion functions in mammals,
consists of hepatocytes and Kupffer, stem, endothelial, stellate and other parenchymal cells …

Restoring mitochondrial function while avoiding redox stress: the key to preventing ischemia/reperfusion injury in machine perfused liver grafts?

J Hofmann, G Otarashvili, A Meszaros, S Ebner… - International journal of …, 2020 - mdpi.com
Mitochondria sense changes resulting from the ischemia and subsequent reperfusion of an
organ and mitochondrial reactive oxygen species (ROS) production initiates a series of …

Mitochondria and ischemia reperfusion injury

R Panconesi, J Widmer, MF Carvalho… - Current opinion in …, 2022 - journals.lww.com
Mitochondria are attractive targets for novel molecules to limit IRI-associated inflammation.
Although dynamic preservation techniques could serve as delivery tool for new therapeutic …

The role of mitochondria in liver ischemia‐reperfusion injury: from aspects of mitochondrial oxidative stress, mitochondrial fission, mitochondrial membrane permeable …

H Zhang, Q Yan, X Wang, X Chen… - Oxidative medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …

Mitochondrial dysfunction and autophagy in hepatic ischemia/reperfusion injury

KL Go, S Lee, I Zendejas, KE Behrns… - BioMed research …, 2015 - Wiley Online Library
Ischemia/reperfusion (I/R) injury remains a major complication of liver resection,
transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic …

[PDF][PDF] Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

N Goikoetxea‐Usandizaga, M Serrano‐Maciá… - …, 2022 - Wiley Online Library
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is the leading
cause of early posttransplantation organ failure as mitochondrial respiration and ATP …