[HTML][HTML] Visualizing group II intron catalysis through the stages of splicing
Group II introns are self-splicing ribozymes that share a reaction mechanism and a common
ancestor with the eukaryotic spliceosome, thereby providing a model system for …
ancestor with the eukaryotic spliceosome, thereby providing a model system for …
Visualizing group II intron dynamics between the first and second steps of splicing
Group II introns are ubiquitous self-splicing ribozymes and retrotransposable elements
evolutionarily and chemically related to the eukaryotic spliceosome, with potential …
evolutionarily and chemically related to the eukaryotic spliceosome, with potential …
Now on display: a gallery of group II intron structures at different stages of catalysis
Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA
and RNA. They are considered evolutionary ancestors of the spliceosome, the …
and RNA. They are considered evolutionary ancestors of the spliceosome, the …
Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome
EJ Sontheimer, PM Gordon… - Genes & development, 1999 - genesdev.cshlp.org
The identical reaction pathway executed by the spliceosome and self-splicing group II intron
ribozymes has prompted the idea that both may be derived from a common molecular …
ribozymes has prompted the idea that both may be derived from a common molecular …
Group II intron self-splicing
AM Pyle - Annual Review of Biophysics, 2016 - annualreviews.org
Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and
retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants …
retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants …
[PDF][PDF] Single-molecule analysis of Mss116-mediated group II intron folding
Group II introns are one of the largest self-splicing ribozymes found in organellar genomes
of various eukaryotes such as fungi, plants and some animals as well as in bacterial …
of various eukaryotes such as fungi, plants and some animals as well as in bacterial …
Structural insights into RNA splicing
N Toor, KS Keating, AM Pyle - Current opinion in structural biology, 2009 - Elsevier
Intron splicing is a fundamental biological process whereby noncoding sequences are
removed from precursor RNAs. Recent work has provided new insights into the structural …
removed from precursor RNAs. Recent work has provided new insights into the structural …
Minimal catalytic domain of a group I self-splicing intron RNA
Y Ikawa, H Shiraishi, T Inoue - Nature structural biology, 2000 - nature.com
The self-splicing intron ribozymes have been regarded as primitive forms of the splicing
machinery for eukaryotic pre-mRNAs. The splicing activity of group I self-splicing introns is …
machinery for eukaryotic pre-mRNAs. The splicing activity of group I self-splicing introns is …
Crystal structure of a group II intron in the pre-catalytic state
RT Chan, AR Robart, KR Rajashankar… - Nature structural & …, 2012 - nature.com
Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the
spliceosome. Here we report the 3.65-Å crystal structure of the group II intron from …
spliceosome. Here we report the 3.65-Å crystal structure of the group II intron from …
RNA splicing: group I intron crystal structures reveal the basis of splice site selection and metal ion catalysis
MR Stahley, SA Strobel - Current opinion in structural biology, 2006 - Elsevier
The group I intron has served as a model for RNA catalysis since its discovery 25 years ago.
Four recently determined high-resolution crystal structures complement extensive …
Four recently determined high-resolution crystal structures complement extensive …