Novel drug targets for idiopathic pulmonary fibrosis

G Sgalla, E Cocconcelli, R Tonelli… - Expert review of …, 2016 - Taylor & Francis
ABSTRACT Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal lung disorder of
unknown cause with a highly variable and unpredictable clinical course. The advances …

Current and future treatment landscape for idiopathic pulmonary fibrosis

F Bonella, P Spagnolo, C Ryerson - Drugs, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) remains a disease with poor survival. The pathogenesis
is complex and encompasses multiple molecular pathways. The first-generation antifibrotics …

Exploitation of novel molecular targets to treat idiopathic pulmonary fibrosis: a drug discovery perspective

B Vaidya, R Patel, A Muth… - Current Medicinal …, 2017 - ingentaconnect.com
Background: Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing lung disease
and is caused by excessive lung scarring. IPF-associated severe mortality can be attributed …

Shedding light on developmental drugs for idiopathic pulmonary fibrosis

P Spagnolo, F Bonella, CJ Ryerson… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is an age-related disease of unknown cause.
The disease is characterized by relentless scarring of the lung parenchyma resulting in …

Pharmacological treatment of idiopathic pulmonary fibrosis: current approaches, unsolved issues, and future perspectives

M Kreuter, F Bonella, M Wijsenbeek… - BioMed research …, 2015 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a devastating condition with a 5‐year survival of
approximately 20%. The disease primarily occurs in elderly patients. IPF is a highly …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

Idiopathic pulmonary fibrosis: recent advances on pharmacological therapy

P Spagnolo, TM Maher, L Richeldi - Pharmacology & therapeutics, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal of the idiopathic interstitial
pneumonias with an estimated 5-year survival of approximately 20%. In the last two decades …

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis

S Aryal, SD Nathan - Expert opinion on emerging drugs, 2018 - Taylor & Francis
Introduction: Idiopathic pulmonary fibrosis is a chronic, progressive fibrotic lung disease of
unknown etiology associated with a high morbidity and mortality. The hallmark of the …

Targeted therapy for idiopathic pulmonary fibrosis: where to now?

S Rangarajan, ML Locy, TR Luckhardt, VJ Thannickal - Drugs, 2016 - Springer
Idiopathic pulmonary fibrosis (IPF) is an aging-associated, recalcitrant lung disease with
historically limited therapeutic options. The recent approval of two drugs, pirfenidone and …

[HTML][HTML] Therapeutic targets in idiopathic pulmonary fibrosis

M Kolb, F Bonella, L Wollin - Respiratory medicine, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal interstitial lung
disease. After many drugs failed in clinical trials, improvements in the understanding of the …