Anal fistula is a common disease that needs surgical treatment to be resolved. Despite a
variety of surgical options, the major problem is still to cure complex fistulas without any …

The (peri) anal fistula or fistula-in-ano is defined as an abnormal channel between the anal
canal and the surrounding structures, usually the perianal skin. In many occasions anal …

The aim of this clinical trial (ID Number NCT01803347) was to determine the safety and
efficacy of autologous adipose-derived stem cells (ASCs) for treatment of cryptoglandular …

BACKGROUND: Anal fistula treatment aims to eradicate the fistula, preserve the sphincter,
prevent recurrence, and allow an early return to daily activities for the patient. Because of the …

Anal fistula is a challenging condition both for surgeons and patients. Recurrent fistula,
Crohn's disease, or autoimmune disorders add further complexity to this situation. Numerous …

BACKGROUND: Treatment of cryptoglandular anal fistulas with injection of autologous or
allogenic adipose tissue–derived mesenchymal stem cells has shown promising results …

Background Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that
may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is …

Background: Autologous adipose-derived stem cells may represent a novel approach for the
management of complex fistula-in-ano. After successful phase I and II clinical trials, a phase …

BACKGROUND: Mesenchymal stem cells derived from adipose tissue have been
successfully used to promote sphincter-saving anal fistula healing. OBJECTIVE: The aim of …

Background Perianal fistulas, characterised as granulomatous inflammation of fistulas
around the anal canal, are associated with significant morbidity resulting in a negative …