Background The complement system is part of the innate immune system that clears
pathogens and cellular debris. In the healthy brain, complement influences …

Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …

Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on
microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 …

Background The risk of glaucoma increases significantly with age and exposure to elevated
intraocular pressure, two factors linked with neuroinflammation. The complement cascade is …

Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer
disease; however, their interrelatedness remains poorly understood. The complement …