Oxidative stress in Alzheimer's disease: should we keep trying antioxidant therapies?

MES Ferreira, AS de Vasconcelos… - Cellular and molecular …, 2015 - Springer
The risk of chronic diseases such as Alzheimer's disease is growing as a result of the
continuous increasing average life span of the world population, a syndrome characterized …

Oxidative stress in Alzheimer's disease: implications for prevention and therapy

C Behl - Alzheimer's Disease: Cellular and Molecular Aspects of …, 2005 - Springer
Oxidative stress is a marker of neurodegeneration and has been recently shown to be also
involved in the early stages of the pathogenesis of various neurodegenerative disorders. In …

Oxidative stress in Alzheimer's disease: molecular hallmarks of underlying vulnerability

MS Uddin, MT Kabir - Biological, Diagnostic and Therapeutic Advances in …, 2019 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by
the presence of senile plaques (SPs) and neurofibrillary tangles (NFTs) in the hippocampus …

Antioxidant treatment in Alzheimer's disease: current state

Y Gilgun-Sherki, E Melamed, D Offen - Journal of Molecular Neuroscience, 2003 - Springer
Accumulating data from experimental and human studies indicate that oxidative stress (OS)
plays a major role in the pathogenesis of Alzheimer's disease (AD). The production of …

Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?

PI Moreira, MA Smith, X Zhu, K Honda… - Drug news & …, 2005 - europepmc.org
Oxidative stress is a key factor involved in the development and progression of Alzheimer's
disease, and it is well documented that free radical oxidative damage, particularly of …

Serial review: causes and consequences of oxidative stress in Alzheimer's disease

MA Smith, G Perry, BJ Tabner, S Turnbull… - Free radical biology & …, 2002 - academia.edu
Over the past decade, the study of oxidative stress in relation to the pathogenesis of
Alzheimer's and other neurodegenerative diseases has been transformed from an esoteric …

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

G Perry, PI Moreira, MS Santos… - CNS & Neurological …, 2008 - ingentaconnect.com
Oxidative stress occurs early in the progression of Alzheimer disease, significantly before
the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. All …

Oxidative stress in Alzheimer's disease: why did antioxidant therapy fail?

T Persson, BO Popescu… - Oxidative medicine and …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in the elderly, with
increasing prevalence and no disease‐modifying treatment available yet. A remarkable …

Oxidative stress and amyloid beta toxicity in Alzheimer's disease: intervention in a complex relationship by antioxidants

S Chakrabarti, M Sinha, IG Thakurta… - Current Medicinal …, 2013 - ingentaconnect.com
The elucidation of the intriguing relationship between oxidative stress and Alzheimer's
disease is crucial to understand the pathogenesis of the disease as also to design a suitable …

Alzheimer's disease and oxidative stress: the old problem remains unsolved

PI Moreira, K Honda, Q Liu, G Aliev… - Current Medicinal …, 2005 - ingentaconnect.com
Despite the controversial discussion about amyloid-β as a cause or consequence of
Alzheimer disease pathophysiology, one of the most devastating neurodegenerative …