No vaccines or safe chemotherapy are available for Chagas disease. Pentamidine and
related di-cations are DNA minor groove-binders with broad-spectrum anti-protozoal activity …

Abstract Objectives Aromatic diamidines (ADs) have been recognized as promising
antiparasitic agents. Therefore, in the present work, the in vitro trypanocidal effect of 11 ADs …

Aromatic diamidines are DNA minor groove-binding ligands that display excellent
antimicrobial activity against fungi, bacteria, and protozoa. Due to the currently …

Trypanosoma cruzi is the etiological agent of Chagas disease, affecting approximately 10
million people in the Americas and with some 40 million people at risk. The objective of this …

Aromatic diamidines represent a class of DNA minor groove-binding ligands that exhibit
high levels of antiparasitic activity. Since the chemotherapy for Chagas' disease is still an …

Trypanosoma cruzi is the etiological agent of Chagas disease, an important neglected
illness affecting about 12–14 million people in endemic areas of Latin America. The …

Aromatic diamidines and related compounds are DNA minor groove binders that have been
screened against a variety of pathogenic microorganisms such as bacteria, fungi and …

Due to limited efficacy and considerable toxicity, the therapy for Chagas' disease is far from
being ideal, and thus new compounds are desirable. Diamidines and related compounds …

Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of
individuals in endemic areas of Latin America. One hundred years after the discovery of …

The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz),
is unsatisfactory. In this context, we performed the phenotypic in vitro screening of novel …