A comparative study of normal inspection, autofluorescence and 5‐ALA‐induced PPIX fluorescence for oral cancer diagnosis

CS Betz, H Stepp, P Janda, S Arbogast… - … journal of cancer, 2002 - Wiley Online Library
Fluorescence diagnosis aims to improve the management of oral cancer via early detection
of the malignant lesions and better delimitation of the tumor margins. This paper presents a …

The use of digitized endoscopic imaging of 5‐ALA‐induced PPIX fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo

W Zheng, M Olivo, KC Soo - International journal of cancer, 2004 - Wiley Online Library
aminolevulinic acid (ALA)‐induced protoporphyrin IX (PPIX) fluorescence has shown an
outstanding sensitivity for the assessment of oral lesions, but its application was hampered …

Detection of squamous cell carcinomas and pre‐cancerous lesions in the oral cavity by quantification of 5‐aminolevulinic acid induced fluorescence endoscopic …

W Zheng, KC Soo, R Sivanandan… - Lasers in surgery and …, 2002 - Wiley Online Library
Abstract Background and Objectives Studies of 5‐aminolevulinic acid‐induced
protoporphyrin IX fluorescence have shown a sensitivity of 95–100% for oral cancer …

[HTML][HTML] Fluorescence spectroscopy combined with 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in detecting oral premalignancy

A Sharwani, W Jerjes, V Salih, AJ MacRobert… - … of Photochemistry and …, 2006 - Elsevier
BACKGROUND: Early detection of premalignant/malignant lesions in the oral cavity can
certainly improve the patient's prognosis. This study presents fluorescence imaging with the …

Detection of squamous cell carcinoma of the oral cavity by imaging 5‐aminolevulinic acid‐induced protoporphyrin IX fluorescence

A Leunig, CS Betz, M Mehlmann, H Stepp… - The …, 2000 - Wiley Online Library
Objectives: Early cancer detection is the best way to improve the prognosis of patients with
oral cancer. Therefore this study presents quantitative fluorescence measurements and …

[HTML][HTML] Fluorescence staining of oral cancer using a topical application of 5-aminolevulinic acid: fluorescence microscopic studies

A Leunig, M Mehlmann, C Betz, H Stepp… - … of Photochemistry and …, 2001 - Elsevier
Introduction: Topical application of 5-aminolevulinic acid (5-ALA) by means of a rinsing
solution has been shown to be a promising new procedure in the diagnosis of oral …

Fluorescence imaging and spectroscopy of 5-aminolevulinic acid induced protoporphyrin IX for the dectection of neoplastic lesions in the oral cavity

A Leunig, K Rick, H Stepp, R Gutmann, G Alwin… - The American journal of …, 1996 - Elsevier
BACKGROUND: Semiquantitative fluorescence measurements following topical application
of 5aminolevulinic acid (5-ALA) in 16 patients with neoplastic lesions of the oral cavity were …

In-vivo testing of oral mucosal lesions with an in-house developed portable imaging device and comparison with spectroscopy results

AN Sah, P Kumar, A Pradhan - Journal of Fluorescence, 2023 - Springer
Progression of oral mucosal lesions is generally marked by changes in the concentration of
the intrinsic fluorophores such as collagen, nicotinamide adenine dinucleotide (NADH) …

Topical application of photofrin for photodynamic diagnosis of oral neoplasms

CJ Chang, P Wilder-Smith - Plastic and reconstructive surgery, 2005 - journals.lww.com
Background: The prognosis of patients with oral cancer can be improved by early diagnosis.
Exact demarcation of tumor margins could contribute to optimum results in surgical excision …

Use of autofluorescence and fluorescent probes as a potential diagnostic tool for oral cancer: A systematic review

IFP Lima, LM Brand, JAP de Figueiredo, L Steier… - Photodiagnosis and …, 2021 - Elsevier
Introduction The prognosis of patients with Oral squamous cell carcinoma (OSCC) are
directly related to the stage of development of the tumor at the time of diagnosis, but it is …