[HTML][HTML] Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy

F Mac Gabhann, JW Ji, AS Popel - PLoS computational biology, 2006 - journals.plos.org
Members of the vascular endothelial growth factor (VEGF) family of proteins are critical
regulators of angiogenesis. VEGF concentration gradients are important for activation and …

VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle

F Mac Gabhann, JW Ji… - Journal of applied …, 2007 - journals.physiology.org
Extensive experimental studies have identified vascular endothelial growth factor (VEGF)
concentrations and concentration gradients as major factors in angiogenesis; however …

[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues

MO Stefanini, FTH Wu, F Mac Gabhann, AS Popel - BMC systems biology, 2008 - Springer
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …

Interactions of VEGF isoforms with VEGFR-1, VEGFR-2, and neuropilin in vivo: a computational model of human skeletal muscle

FM Gabhann, AS Popel - American Journal of Physiology …, 2007 - journals.physiology.org
The vascular endothelial growth factor (VEGF) family of cytokines is involved in the
maintenance of existing adult blood vessels as well as in angiogenesis, the sprouting of new …

[HTML][HTML] Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis

P Vempati, AS Popel… - BMC systems …, 2011 - bmcsystbiol.biomedcentral.com
The spatial distribution of vascular endothelial growth factor A (VEGF) is an important
mediator of vascular patterning. Previous experimental studies in the mouse hindbrain and …

[HTML][HTML] Multi-scale computational models of pro-angiogenic treatments in peripheral arterial disease

F Mac Gabhann, JW Ji, AS Popel - Annals of biomedical engineering, 2007 - Springer
The induction of angiogenesis is a promising therapeutic strategy for the amelioration of
peripheral arterial disease (PAD). This occlusive disease results in muscle ischemia, and …

[HTML][HTML] A two-compartment model of VEGF distribution in the mouse

P Yen, SD Finley, MO Engel-Stefanini, AS Popel - PloS one, 2011 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …

[HTML][HTML] A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse

LH Chu, VC Ganta, MH Choi, G Chen, SD Finley… - Scientific reports, 2016 - nature.com
Angiogenesis is the growth of new blood vessels from pre-existing microvessels. Peripheral
arterial disease (PAD) is caused by atherosclerosis that results in ischemia mostly in the …

Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise

JW Ji, F Mac Gabhann… - American Journal of …, 2007 - journals.physiology.org
VEGF is a key promoter of angiogenesis and a major target of proangiogenic therapy for
peripheral arterial disease (PAD). Greater understanding of VEGF angiogenic signaling and …

[HTML][HTML] Expression of VEGF receptors on endothelial cells in mouse skeletal muscle

PI Imoukhuede, AS Popel - 2012 - journals.plos.org
VEGFR surface localization plays a critical role in converting extracellular VEGF signaling
towards angiogenic outcomes, and the quantitative characterization of these parameters is …