Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro

CL Grosskreutz, B Anand-Apte, C Dupláa… - Microvascular …, 1999 - Elsevier
Angiogenesis is a complex process that includes recruitment and proliferation of mural cells—
smooth muscle cells (SMC) and pericytes. Vascular endothelial growth factor (VEGF) has …

VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses

TT Rissanen, JE Markkanen, M Gruchala… - Circulation …, 2003 - Am Heart Assoc
Optimal angiogenic and lymphangiogenic gene therapy requires knowledge of the best
growth factors for each purpose. We studied the therapeutic potential of human vascular …

Mathematical modeling of tumor-induced angiogenesis

MAJ Chaplain, SR McDougall… - Annu. Rev. Biomed …, 2006 - annualreviews.org
Angiogenesis, the growth of a network of blood vessels, is a crucial component of solid
tumor growth, linking the relatively harmless avascular and the potentially fatal vascular …

Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells

F Mac Gabhann, AS Popel - American Journal of …, 2004 - journals.physiology.org
Placental growth factor (PlGF) competes with vascular endothelial growth factor (VEGF) for
binding to VEGF receptor (VEGFR)-1 but does not bind VEGFR2. Experiments show that …

The role of the microvascular network structure on diffusion and consumption of anticancer drugs

P Mascheroni, R Penta - International journal for numerical …, 2017 - Wiley Online Library
We investigate the impact of microvascular geometry on the transport of drugs in solid
tumors, focusing on the diffusion and consumption phenomena. We embrace recent …

Restoration of blood flow and evaluation of corresponding angiogenic events by scanning electron microscopy after a single dose of VEGF in a model of peripheral …

T Kofidis, D Nolte, AR Simon, A Metzakis, L Balsam… - Angiogenesis, 2002 - Springer
The angiogenic effect of vascular endothelial growth factor (VEGF) has typically been
assessed by indirect methods, including microsphere injection and angiography. Here, we …

Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia

G Von Degenfeld, A Banfi, ML Springer… - The FASEB …, 2006 - Wiley Online Library
The critical role of vascular endothelial growth factor (VEGF) expression levels in
developmental angiogenesis is well established. Nonetheless, the effects of different local …

Combining in silico and in vitro models to inform cell seeding strategies in tissue engineering

R Coy, G Al-Badri, C Kayal… - Journal of the …, 2020 - royalsocietypublishing.org
The seeding density of therapeutic cells in engineered tissue impacts both cell survival and
vascularization. Excessively high seeded cell densities can result in increased death and …

Blood flow can signal during angiogenesis not only through mechanotransduction, but also by affecting growth factor distribution

S Ghaffari, RL Leask, EAV Jones - Angiogenesis, 2017 - Springer
Growth factors, such as VEGF, promote the sprouting of new blood vessels. Growth factors
are generally produced far from the endothelium, and the transport of these proteins is often …

Computational models of sprouting angiogenesis and cell migration: towards multiscale mechanochemical models of angiogenesis

TAM Heck, MM Vaeyens… - … Modelling of Natural …, 2015 - mmnp-journal.org
Angiogenesis, the formation of new bloods vessels from the existing vasculature, is a
process that is essential during development and regeneration of tissues, and that plays a …