To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …

The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …

The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
an important target for vaccine and drug development. However, the rapid emergence of …

The widespread coronavirus SARS-CoV-2 has already infected over 4 million people
worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies …

Abstract In late December 2019 in Wuhan, China, several patients with viral pneumonia
were identified as 2019 novel coronavirus (2019‐nCoV). So far, there are no specific …

Host-cell cysteine proteases play an essential role in the processing of the viral spike protein
of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that …

Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-
degrading elastase-related serine proteases. Thus, CatC appears as a potential therapeutic …

There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current
COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents a promising …

Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a
promising drug target for novel antivirals against SARS-CoV-2. The marine natural product …

We read with great interest the editorial by Baron et al. suggesting the potential use of
teicoplanin as an alternative drug to treat patients infected with severe acute respiratory …