In the era of “Bad Bugs, No Drugs,” optimizing antibiotic therapy against multi-drug resistant
(MDR) pathogens is crucial. Mathematical modelling has been employed to further optimize …

Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the
research and development (R&D) of new drugs, post-market monitoring, and continued …

Objective Antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) principles and PK/PD
models have been essential in characterizing the mechanism of antibiotic bacterial killing …

Significant progress in previous decades has led to several methodologies developed to
facilitate the design of optimal antimicrobial dosing. In this review, we highlight common …

Effective antimicrobial chemotherapy integrates pharmacology and microbiology to achieve
the most favorable clinical and microbiologic outcomes. Understanding such relationships …

Suboptimal use of antimicrobial drugs contributes to increasing antimicrobial resistance and
may lead to therapeutic failure at the individual patient level. Considering the significant …

The emerging discipline of Quantitative Systems Pharmacology (QSP) enables the
integration of quantitative experimental data describing the interactions between the various …

Pharmacodynamic modeling has been increasingly used as a decision support tool to guide
dosing regimen selection, both in the drug development and clinical settings. Killing by …

Pharmacometrics plays an important role in rational dosing design of antimicrobial therapy
by defining the relationship between dose, dosing interval, drug concentration, bacterial …

Translational PK/PD modeling has emerged as a critical technique for quantitative analysis
of the relationship between dose, exposure and response of antibiotics. By combining model …