Genetic contribution to variable human CYP3A-mediated metabolism
The human CYP3A subfamily plays a dominant role in the metabolic elimination of more
drugs than any other biotransformation enzyme. CYP3A enzyme is localized in the liver and …
drugs than any other biotransformation enzyme. CYP3A enzyme is localized in the liver and …
Genetic variability in CYP3A5 and its possible consequences
The cytochrome P450 3A (CYP3A) subfamily members are the most abundant and important
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …
drug-metabolizing enzymes in humans, and wide interindividual variability in CYP3A …
CYP2A6 genetic variation and potential consequences
Human cytochrome P450 2A6 (CYP2A6) has been shown to have large interindividual and
interethnic variability in levels of expression and activity. This is thought to be largely due to …
interethnic variability in levels of expression and activity. This is thought to be largely due to …
Genetics of the variable expression of CYP3A in humans
L Wojnowski - Therapeutic drug monitoring, 2004 - journals.lww.com
CYP3A isozymes participate in the metabolism of 45–60% of currently used drugs and of a
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …
variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A …
Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity
A Westlind‐Johnsson, R Hermann… - Clinical …, 2006 - Wiley Online Library
Background The major drug‐metabolizing enzyme cytochrome P450 (CYP) 3A4 is
genetically conserved. One outlier of Brazilian descent was found in a clinical …
genetically conserved. One outlier of Brazilian descent was found in a clinical …
Cytochrome P450 in pharmacogenetics: an update
A Tornio, JT Backman - Advances in pharmacology, 2018 - Elsevier
Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …
The genetic determinants of the CYP3A5 polymorphism
E Hustert, M Haberl, O Burk, R Wolbold… - Pharmacogenetics …, 2001 - journals.lww.com
CYP3A proteins comprise a significant portion of the hepatic cytochrome P450 (CYP) protein
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …
and they metabolize aroud 50% of drugs currently in use. The dissection of the individual …
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance
Polymorphisms in drug-metabolizing enzymes and drug transporters contribute to wide and
inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well …
inheritable variability in drug pharmacokinetics, response and toxicity. One of the less well …
Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans
A Paulussen, K Lavrijsen, H Bohets… - Pharmacogenetics …, 2000 - journals.lww.com
Cytochrome P450 3A subfamily members (CYP3A) are the most abundant liver cytochrome
P450 forms, responsible for the biotransformation of over 50% of all drugs. The expression …
P450 forms, responsible for the biotransformation of over 50% of all drugs. The expression …