Background Interferon-alpha (IFN α)-associated mood disorder is a major complication of
treatment for chronic hepatitis C. Method The authors report on three patients infected with …

Objective: Treatment with recombinant interferon is associated with high rates of psychiatric
comorbidity. We investigated the relation between catabolism of the essential amino acid …

Background Risk of depression and suicide in patients on interferon remains also after the
treatment, the pathogenesis of which is still unclear. We aimed to determine the influence of …

Method Patients. Ten patients (mean [SD] age 45 years [12.7], range 29-63; three males,
seven females) with chronic hepatitis C eligible to receive IFN-alpha (1.5 microg/kg/week …

There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …

Aims: Depression and other psychiatric disorders are frequent in HCV-infected patients,
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …

The currently recommended therapy for chronic hepatitis C (HCV) is a combination of
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …

Introduction: Treatment of hepatitis C with peginterferon induces psychiatric side effects.
These might include changes in serotonergic function. Methods: Twenty-two hepatitis C …

Chronic hepatitis is often associated with neuropsychiatric disorders. Interferon (IFN) is the
drug most widely used to treat this disease, and its side effects, such as depression, often …

Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …