Three Cases of Successful Tryptophan Add-On or Monotherapy of Hepatitis C and IFNα-Associated Mood Disorders
M Schaefer, J Winterer, R Sarkar, R Uebelhack… - Psychosomatics, 2008 - Elsevier
Background Interferon-alpha (IFN α)-associated mood disorder is a major complication of
treatment for chronic hepatitis C. Method The authors report on three patients infected with …
treatment for chronic hepatitis C. Method The authors report on three patients infected with …
Irritability rather than depression during interferon treatment is linked to increased tryptophan catabolism
S Russo, IP Kema, EB Haagsma, JC Boon… - Psychosomatic …, 2005 - journals.lww.com
Objective: Treatment with recombinant interferon is associated with high rates of psychiatric
comorbidity. We investigated the relation between catabolism of the essential amino acid …
comorbidity. We investigated the relation between catabolism of the essential amino acid …
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment
T Pawlowski, K Malyszczak, M Inglot… - …, 2018 - Elsevier
Background Risk of depression and suicide in patients on interferon remains also after the
treatment, the pathogenesis of which is still unclear. We aimed to determine the influence of …
treatment, the pathogenesis of which is still unclear. We aimed to determine the influence of …
Impact of interferon alpha immunotherapy on tryptophan metabolism in patients with chronic hepatitis C. Results of a pilot studies on ten patients
J Vignau, O Costisella, V Canva, M Imbenotte… - L'encephale, 2008 - europepmc.org
Method Patients. Ten patients (mean [SD] age 45 years [12.7], range 29-63; three males,
seven females) with chronic hepatitis C eligible to receive IFN-alpha (1.5 microg/kg/week …
seven females) with chronic hepatitis C eligible to receive IFN-alpha (1.5 microg/kg/week …
Increased depressive ratings in patients with hepatitis C receiving interferon-α–based immunotherapy are related to interferon-α–induced changes in the serotonergic …
S Bonaccorso, V Marino, A Puzella… - Journal of clinical …, 2002 - journals.lww.com
There is now evidence that repeated administration of interferon-α (IFN-α) to patients with
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …
chronic active hepatitis and cancers induces depressive symptoms. There is also evidence …
HCV patients, psychopathology and tryptophan metabolism: analysis of the effects of pegylated interferon plus ribavirin treatment
AL Zignego, A Cozzi, R Carpenedo, C Giannini… - Digestive and Liver …, 2007 - Elsevier
Aims: Depression and other psychiatric disorders are frequent in HCV-infected patients,
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …
especially during interferon treatment. The molecular mechanism (s) maderlying this finding …
Neuropsychiatric effects and type of IFN-α in chronic hepatitis C
M Malaguarnera, A Laurino, I Di Fazio… - Journal of Interferon & …, 2001 - liebertpub.com
Chronic hepatitis is often associated with neuropsychiatric disorders. Interferon (IFN) is the
drug most widely used to treat this disease, and its side effects, such as depression, often …
drug most widely used to treat this disease, and its side effects, such as depression, often …
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C
S Comai, L Cavalletto, L Chemello… - Pharmacological …, 2011 - Elsevier
The currently recommended therapy for chronic hepatitis C (HCV) is a combination of
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …
pegylated interferon-alpha (PEG-IFN alpha) and ribavirin. Psychiatric disorders, including …
Psychiatric side effects and fluctuations in serotonergic parameters in the treatment of chronic hepatitis C infection
G Bezemer, AR Van Gool, D Fekkes, JM Vrolijk… - …, 2012 - karger.com
Introduction: Treatment of hepatitis C with peginterferon induces psychiatric side effects.
These might include changes in serotonergic function. Methods: Twenty-two hepatitis C …
These might include changes in serotonergic function. Methods: Twenty-two hepatitis C …
[HTML][HTML] Disturbances of tryptophan metabolism and risk of depression in HCV patients treated with IFN-alpha
GF Oxenkrug, WA Turski, W Zgrajka… - Journal of infectious …, 2014 - ncbi.nlm.nih.gov
Depression is a common side-effect of interferon (IFN)-alpha treatment of hepatitis C virus
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …
(HCV) infection and melanoma. Disturbances of tryptophan (TRP) metabolism might …