egylated interferon-alpha with ribavirin is the most effective therapy for chronic hepatitis C
infection, 1, 2 but psychiatric patients often discontinue IFN-alpha because of its mood side …

We have shown that treatment with interleukin-2 (IL-2) or interferon-α (IFNα) may induce
depressive symptoms and activation of the cytokine network and that IL-2 treatment may …

Abstract Introduction/Aim: Chronic viral hepatitis and its treatment with interferon (IFN) have
an impact on patients' quality of life. The purpose of this study was to evaluate the degree of …

Background Interferon α therapy for hepatitis C can exacerbate preexisting depression.
Bipolar disorder frequently presents as depressive symptoms that are indistinguishable from …

Conclusion A better understanding of pathophysiologic mechanisms underlying psychiatric
side-effects of IFNalpha is essential to extend access to treatment to some categories of …

DEPRESSIVE SYMPTOMS IN PATIENTS WITH HEPATITIS C TREATED WITH
PEGYLATED INTERFERON ALPHA THERAPY: A 24-WEEK PROSPECTIVE STUDY Page …

Discussion Mechanisms for direct effects of IFNα on the CNS, such as decrease of
tryptophan availability, central serotonergic deficit, increase of cortisol after activation of the …

Objective: To estimate the frequency of depression among hepatitis C positive patients.
Material and Methods: This descriptive cross sectional study was conducted in the …

Background Interferon alpha (IFN-α) therapy for chronic hepatitis C (CHC) infection is
commonly associated with neuropsychiatric side effects including depressive …

Objective To assess the incidence rate and severity of depressive symptoms in different time
points (12, 24 and 48 weeks) in Brazilian patients with HCV treated with PEG IFN plus …