Abstract Background: Interferon-α (IFN-α) treatment is often associated with psychiatric side
effects and has been found to lower the amount of tryptophan (TRP) available to the brain …

Objective. Neuropsychiatric symptoms are common in patients with chronic hepatitis C
(CHC) and can potentially be exacerbated by interferon-alpha treatment. Such symptoms …

Opinion statement Patients with hepatitis C virus (HCV) infection have a higher prevalence
of psychiatric illness compared with the general US population, and the prevalence of HCV …

In this issue of the Journal, two papers are devoted to a major clinical problem associated
with the current treatment of chronic hepatitis C (HCV): depression [1, 2]. It is important to …

Abstract Interferon alpha (IFN-α)-treated patients commonly develop depression during the
therapy period. Although most IFN-α-induced depressive disorders achieve remission after …

Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving
interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2, 3 …

Recent evidence has demonstrated the efficacy of pegylated interferon-alpha (IFN-α) in
treating hepatitis C virus infection. Neuropsychiatric complications commonly occur during …

In recent years, research on interferon (IFN)‐induced depressive symptoms in antivirally
treated patients suffering from chronic hepatitis C (CHC) has considerably intensified …

Background Tryptophan metabolism via the kynurenine pathway is considered the link
between the immune and endocrine systems. Dysregulation of serotonergic transmission …