Gestational chronodisruption impairs circadian physiology in rat male offspring, increasing the risk of chronic disease

N Mendez, D Halabi, C Spichiger, ER Salazar… - …, 2016 - academic.oup.com
Chronic exposure to light at night, as in shift work, alters biological clocks (chronodisruption),
negatively impacting pregnancy outcome in humans. Actually the interaction of maternal and …

Maternal circadian rhythms and the programming of adult health and disease

TJ Varcoe, KL Gatford… - American Journal of …, 2018 - journals.physiology.org
The in utero environment is inherently rhythmic, with the fetus subjected to circadian
changes in temperature, substrates, and various maternal hormones. Meanwhile, the fetus is …

Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function

ER Salazar, HG Richter, C Spichiger… - The Journal of …, 2018 - Wiley Online Library
Key points Light at night is essential to a 24/7 society, but it has negative consequences on
health. Basically, light at night induces an alteration of our biological clocks, known as …

Circadian rhythms in the fetus and newborn: significance of interactions with maternal physiology and the environment

M Serón-Ferré, HG Richter, GJ Valenzuela… - Prenatal and postnatal …, 2016 - Springer
Timing of balanced and precise daily delivery of oxygen, nutrients, hormones, and
biophysical cues from mother to fetus is essential for fetal growth and successful transition to …

Programming effects of maternal stress on the circadian system of adult offspring

S Yun, EJ Lee, HK Choe, GH Son, K Kim… - … & Molecular Medicine, 2020 - nature.com
Maternal stress has long-lasting influences on the brain functions of offspring, and several
brain regions have been proposed to mediate such programming. Although perinatal …

Chronodisruption: An untimely cause of preterm birth?

L Reschke, R McCarthy, ED Herzog, JC Fay… - Best Practice & …, 2018 - Elsevier
Circadian rhythms, endogenous and entrainable adaptations to 24-hour cycles of light and
dark, influence almost all physiologic functions. Emerging evidence suggests that the …

Light and circadian signaling pathway in pregnancy: Programming of adult health and disease

CN Hsu, YL Tain - International journal of molecular sciences, 2020 - mdpi.com
Light is a crucial environmental signal that affects elements of human health, including the
entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase …

Environmental perturbation of the circadian clock disrupts pregnancy in the mouse

KC Summa, MH Vitaterna, FW Turek - PloS one, 2012 - journals.plos.org
Background The circadian clock has been linked to reproduction at many levels in
mammals. Epidemiological studies of female shift workers have reported increased rates of …

Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light

N Mendez, L Abarzua-Catalan, N Vilches… - 2012 - journals.plos.org
Surprisingly, in our modern 24/7 society, there is scant information on the impact of
developmental chronodisruption like the one experienced by shift worker pregnant women …

The impact of prenatal circadian rhythm disruption on pregnancy outcomes and long-term metabolic health of mice progeny

TJ Varcoe, A Voultsios, KL Gatford… - Chronobiology …, 2016 - Taylor & Francis
Animal studies demonstrate that circadian rhythm disruption during pregnancy can be
deleterious to reproductive capacity and the long-term health of the progeny. Our previous …