Aim: Gallstone disease is an important cause of abdominal morbidity Organic anion
transport protein 1B1 (OATP1B1)(encoded by SLCO1B1) is a major transporter protein for …

Background & objectives: Organic anion transport protein 1B1 (OATP1B1) is a major
transporter protein for bile salt uptake in the enterohepatic circulation of bile salts. As the role …

Methods Fasting blood samples were drawn from 24 healthy volunteers with SLCO1B1 c.
388AA-c. 521TT (* 1A/* 1A) genotype, eight with c. 388GG-c. 521TT (* 1B/* 1B) genotype, 24 …

There is growing evidence that gallstone formation may be genetically determined. Recent
studies have shown that polymorphism of genes encoding proteins involved in bile acid …

Background Cholelithiasis is a multifactorial process and several mechanisms of gallstone
formation have been postulated. As one of these mechanisms, a decreased expression of …

Objective Cholesterol gallstone disease (CGD) is a multifactorial and multistep disease.
Apart from female gender and increasing age being the documented non-modifiable risk …

Background Recently, a single nucleotide polymorphism (SNP) rs9514089 in SLC10A2
(apical sodium-dependent bile acid transporter gene) has been identified as a susceptibility …

Background Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1
(encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate the hepatic uptake of endogenous …

Abstract Background and Aim: The major transporter responsible for bile acid uptake from
the intestinal lumen is the apical sodium‐dependent bile acid transporter (ASBT, SLC10A2) …

Abstract Background and Aim: Gallstone formation is characterized by the abnormal
regulation of cholesterol trafficking and solubilization. The prevalence of gallstone disease …