Simple Summary Pancreatic cancer tissue is resistant to anticancer drugs because of its
complex microenvironment. Cancer-associated fibroblasts (CAFs) are an important source …

Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a
fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and …

Background Patient-derived tumor models are the new standard for pre-clinical drug testing
and biomarker discovery. However, the emerging technology of primary pancreatic cancer …

For many years, cell lines and animal models have been essential to improve our
understanding of the basis of cell metabolism, signaling, and genetics. They also provided …

Simple Summary Among all types of cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
has one of the lowest survival rates, partly due to the failure of current chemotherapeutics …

Pancreatic cancer is a highly lethal form of digestive malignancy that poses significant
health risks to individuals worldwide. Chemotherapy‐based comprehensive treatment is the …

The aggressiveness of pancreatic ductal adenocarcinoma (PDAC) is affected by the tumor
microenvironment (TME). In this study, to recapitulate the PDAC TME ex vivo, we cocultured …

Despite recent advances in the treatment of cancer, pancreatic ductal adenocarcinoma
(PDAC) still retains the worst survival rate of common malignancies. Late diagnosis and lack …

Cell models are indispensable for the research and development of cancer therapies.
Cancer medications have evolved with the establishment of various cell models. Patient …

Pancreatic cancer is a rapidly progressing disease with a poor prognosis. We still have
many questions about the pathogenesis, early diagnosis and precise treatment of this …