Tafenoquine is being developed for radical cure and post-exposure prophylaxis of
Plasmodium vivax malaria. In an open-label study, 1512 Australian Defence Force …

On return from duty in North Solomons Province (including Bougainville Island), Papua New
Guinea, 586 Australian Defence Force personnel received either primaquine (14-d) or …

Tafenoquine was used to treat Plasmodium vivax malaria cases who had previously failed
treatment with chloroquine and primaquine. Chloroquine was followed by a loading dose of …

Background. Tafenoquine is an 8-aminoquinoline developed as a more effective
replacement for primaquine. In a previous dose-ranging study in Thailand, 3 tafenoquine …

Background Clinical effectiveness of previous regimens to treat Plasmodium vivax infection
have been hampered by compliance. We aimed to assess the dose–response, safety, and …

We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-
resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 …

Abstract We tested tafenoquine (WR 238605), a new long-acting 8-aminoquinoline, for its
ability to prevent malaria in an area that is holoendemic for Plasmodium falciparum. In a …

Background Tafenoquine is an investigational 8-aminoquinoline for the prevention of
Plasmodium vivax relapse. Tafenoquine has a long half-life and the potential for more …

Since the eighties, the Au st ralian Defence Fo rce has dep l oyed soldiers in malaria-
endemic are as: C ambodia, S omalia, R wa nda, B ou ga i nv ille, and East Ti mo r. Curre nt …

Abstract Background Treatment of Plasmodium vivax malaria requires the clearing of
asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared …