Radiation therapy planning of thoracic tumors: A review of challenges associated with lung toxicities and potential perspectives of gallium-68 lung PET/CT imaging

F Lucia, M Rehn, F Blanc-Béguin, PY Le Roux - Frontiers in Medicine, 2021 - frontiersin.org
Despite the introduction of new radiotherapy techniques, such as intensity modulated
radiation therapy or stereotactic body radiation therapy, radiation induced lung injury …

A prospective observational study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer

S Siva, J Callahan, T Kron, OA Martin, MP MacManus… - BMC cancer, 2014 - Springer
Background Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is
the leading cause of cancer deaths. Radiation therapy (RT), alone or in combination with …

[HTML][HTML] Mid-treatment adaptive planning during thoracic radiation using 68 Ventilation-Perfusion Positron emission tomography

N Bucknell, N Hardcastle, R Gunewardena… - Clinical and …, 2023 - Elsevier
Abstract Four-Dimensional Gallium 68 Ventilation-Perfusion Positron Emission Tomography
(68 Ga-4D-V/Q PET/CT) allows for dynamic imaging of lung function. To date there has been …

[HTML][HTML] Anatomic, functional and molecular imaging in lung cancer precision radiation therapy: treatment response assessment and radiation therapy personalization

M MacManus, S Everitt, T Schimek-Jasch… - Translational Lung …, 2017 - ncbi.nlm.nih.gov
This article reviews key imaging modalities for lung cancer patients treated with radiation
therapy (RT) and considers their actual or potential contributions to critical decision-making …

PET and PET–CT in radiation treatment planning for lung cancer

C Aristei, L Falcinelli, B Palumbo… - Expert review of …, 2010 - Taylor & Francis
This review analyzes PET images in radiotherapy treatment planning for lung cancer
patients and discusses the most controversial current issues. Computed tomography images …

Single-arm prospective interventional study assessing feasibility of using gallium-68 ventilation and perfusion PET/CT to avoid functional lung in patients with stage III …

N Bucknell, N Hardcastle, P Jackson, M Hofman… - BMJ open, 2020 - bmjopen.bmj.com
Background In the curative-intent treatment of locally advanced lung cancer, significant
morbidity and mortality can result from thoracic radiation therapy. Symptomatic radiation …

Ventilation/perfusion positron emission tomography—based assessment of radiation injury to lung

S Siva, N Hardcastle, T Kron, M Bressel… - International Journal of …, 2015 - Elsevier
Purpose To investigate 68 Ga-ventilation/perfusion (V/Q) positron emission tomography
(PET)/computed tomography (CT) as a novel imaging modality for assessment of perfusion …

The HI-FIVE trial: A prospective trial using 4-dimensional 68Ga ventilation-perfusion positron emission tomography-computed tomography for functional lung …

NW Bucknell, N Hardcastle, B Woon, L Selbie… - International Journal of …, 2023 - Elsevier
Purpose Functional lung avoidance (FLA) radiation therapy aims to spare regions of
functional lung to reduce toxicity. We report the results of the first prospective trial of FLA …

Current concepts in F18 FDG PET/CT-based radiation therapy planning for lung cancer

P Lee, P Kupelian, J Czernin, P Ghosh - Frontiers in oncology, 2012 - frontiersin.org
Radiation therapy is an important component of cancer therapy for early stage as well as
locally advanced lung cancer. The use of F18 FDG PET/CT has come to the forefront of lung …

The role of positron emission tomography/computed tomography in radiation therapy planning for patients with lung cancer

MP Mac Manus, RJ Hicks - Seminars in nuclear medicine, 2012 - Elsevier
Positron emission tomography (PET)/computed tomography (CT) has rapidly assumed a
critical role in the management of patients with locoregionally advanced lung cancers who …