Inability to meet protein folding demands within the endoplasmic reticulum (ER) activates the
unfolded protein response (UPR), a signaling pathway with both adaptive and apoptotic …

The endoplasmic reticulum (ER) is the cellular site of newly synthesized secretory and
membrane proteins. Such proteins must be properly folded and posttranslationally modified …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …

The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane
proteins are synthesized and folded. Correctly folded proteins exit the ER and are …

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …

The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular
activities and survival. Conditions that interfere with ER function lead to the accumulation …

Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …

The endoplasmic reticulum (ER) is recognized primarily as the site of synthesis and folding
of secreted and membrane‐bound proteins. The ER provides stringent quality control …

The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is
triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells …