The kallikrein kinin system (KKS) consists of serine proteases involved in the production of
peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS …

Human tissue kallikrein is a serine protease implicated in the pathology of various
inflammatory disorders. As one of the two principal enzymes that generate proinflammatory …

Publisher Summary This chapter focuses primarily on the molecular biology of the tissue
kallikrein (KLK) gene family. The chapter emphasizes on the differences in gene structure …

Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …

The human kallikrein (KLK)-related peptidases are the largest family of serine peptidases,
comprising 15 members (KLK1–15) and with the majority (KLK4–15) being identified only …

The kallikrein–kinin system of mammals involves the sequential action of several well-
characterized proteolytic enzymes. 1, 2 Activation of Factor XII (Hageman factor) in blood at …

The human tissue kallikrein (KLK) family contains 15 secreted serine proteases that are
expressed in a wide range of tissues and have been implicated in different physiological …

Introduction Tissue kallikrein (or glandular kallikrein as it was called first) is a late bloomer.
Sixty-three years after its discovery in urine as a hypotensive material andhalf-a-century after …

F or forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS).
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …

We report the enzymatic properties and substrate specificity of human recombinant KLK3 in
the presence of glycosaminoglycans (GAGs) and sodium citrate. This salt is highly …