Genome editing therapies represent a significant advancement in next‐generation,
precision medicine for the management of haematological diseases, and CRISPR/Cas9 has …

Summary The Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR‐associated (Cas) 9 platform offers an efficient way of making precise …

Advances in genome engineering in the last decade, particularly in the development of
programmable nucleases, have made it possible to edit the genomes of most cell types …

The recent advent of the Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)‐CRISPR associated protein 9 (Cas9) system for precise genome editing has …

We are molecular toolmakers. The tools we design, synthesize, and create disrupt or repair
the human genome. Either outcome can be achieved using bio-molecular scissors generally …

The development of genome editing tools capable of modifying specific genomic sequences
with unprecedented accuracy has opened up a wide range of new possibilities in targeted …

Highlights•Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 is a
powerful tool for genome editing in hematopoietic cells, including primary hematopoietic …

Hematological malignancies (HM) are a group of neoplastic diseases that are usually
heterogenous in nature due to the complex underlying genetic aberrations in which …

Highlights•CRISPR/Cas9 overcomes limitations of earlier targeted nuclease-mediated
methods.•CRISPR/Cas9 allows for insertions/deletions of multiple alleles in a single …

Blood disorders are group of diseases including hematological neoplasms, clotting
disorders and orphan immune deficiency diseases that affects human health. Current …