Blood disorders are a group of diseases including hematological neoplasms, clotting
disorders and orphan immune deficiency diseases that affects human health. Current …

The recent introduction of clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR associated protein (Cas) systems, offer an array of genome and …

In recent years, tremendous advances have been made in the use of gene editing to
precisely engineer the genome. This technology relies on the activity of a wide range of …

In recent years, clustered regularly interspaced short palindromic repeats (CRISPRs) and
CRISPR-associated (Cas) protein have emerged as a revolutionary gene editing tool to treat …

There have been significant advances in understanding the genetics and molecular basis of
a number of hematological disorders in recent years, but clinical interventions, such as …

Highlights•Unwanted on-target mutation occurs after CRISPR–Cas9 cleavage.•Assessment
of comprehensive on-target outcomes is necessary.•Clinical genomic engineering requires …

The ongoing advent of genome editing with programmable nucleases, including zinc‐finger
nuclease (ZFN), TAL effector nuclease (TALEN), and Clustered Regularly Interspaced Short …

CRISPR-Cas is a versatile genome editing technology that has been broadly applied in both
basic research and translation medicine. Ever since its discovery, the bacterial derived …

Though the dust is still settling on the contentious CRISPR–Cas9 patent battle, the
conversation surrounding this revolutionary technology has only just begun. Since the …

Clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing
has begun to transform the treatment landscape of genetic diseases. The history of the …