Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes
worldwide. As pre-menopausal women are less likely to develop CRC compared to age …

Worldwide, colorectal cancer has a higher incidence rate in men than in women, suggesting
a protective role for sex hormones in the development of the disease. Preclinical data …

Estrogens have been implicated in the pathogenesis of various cancer types, including
colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

This perspective on Jin et al.(beginning on page 910 in this issue of the journal) discusses
the importance of estrogen signaling in colorectal carcinogenesis, with a focus on estrogen …

Hormones have become a useful therapeutic aspect of clinical endocrinology but how to use
them to optimize the health benefits and avoid adverse effects is a major challenge …

Background Estrogen receptor β (ERβ) is a potential tumor-suppressor gene in colorectal
cancer (CRC). This hypothesis is supported by clinical and laboratory observations. Aim In …

We reported that high estrogen receptor beta (ERβ) expression is independently associated
with better prognosis in female colorectal cancer (CRC) patients. However, estrogen …

Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in
the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic …